Study of Serum Adenosine Deaminase and Transaminases in type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Adenosine deaminase (ADA) is an enzyme present in most human tissues. It is also known as adenosine aminohydrolase and involved in purine metabolism. It is an important marker of inflammation. Elevation of the main serum transaminases, aspartate transaminase (AST) and alanine transaminase (ALT) levels indicates liver cell injury. Liver is the main organ that regulates carbohydrate metabolism. Diabetes mellitus is associated with increased risk of liver disease. The aims of the study is to measure serum ADA and transaminases levels in type 2 diabetes mellitus (T2DM) subjects and healthy controls. And to find out any correlation between ADA, fasting blood sugar (FBS), Glycated haemoglobin (HbA1c) and transaminases The study was carried out in 60 cases of T2DM and 30 healthy controls. Serum ADA was measured spectrophotometrically based on Guisti and Galanti method. FBS, HbA1c, ALT and AST were measured in all the study subjects. Statistical analysis was done by using SPSS version 20. In this study, the mean serum ADA was significantly increasely in T2DM as compared to controls. Mean FBS, HbA1c, AST and ALT were also significantly increased (p < 0.05) in T2DM as compared to controls. Serum ADA was found to have significant positive correlation with FBS and glycemic status in T2DM. No significant correlation was found between serum ADA and transaminases. The present study shows that there may be ongoing inflammation and hepatic injury in diabetic patients. Estimation of liver enzymes along with serum ADA may help in early detection of derangement of liver function and to prevent further complications.
Authors and Affiliations
Sujeeta Oinam, R. K. Vidyabati Devi, Th. Bhimo Singh, WaikhomGyaneshwar Singh
Keywords
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- DOI 10.9790/0853-1710041216.
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