STUDY OF SERUM ALBUMIN LEVEL AND ITS PROGNOSTIC SIGNIFICANCE IN SCRUB TYPHUS IN SOUTH EAST RAJASTHAN
Journal Title: PARIPEX-Indian Journal of Research - Year 2019, Vol 8, Issue 1
Abstract
Introduction: Scrub typhus is a zoonotic bacterial infection caused by Orientia tsutsugamushi. It is maintained by transovarial transmission in trombiculid mites. Aim: To study prognostic significance of serum albumin level in scrub typhus patients in south east Rajasthan. Method: Patients with scrub typhus were divided into three groups based on serum albumin level; Group I/Normal albumin (Serum Albumin level >3.5gm/dl), Group II/Mild hypoalbuminemia (Serum Albumin level 2.5-3.5gm/dl) and Group III/Marked hypoalbuminemia (Serum Albumin level < 2.5gm/dl). Patients were monitored for complication and outcome during hospital stay and data was analysed. Result: A total of 114 patients were included, of which 34 patients (29.8%) were categorized in Group I, 58 patients (50.9%) in Group II and 22 patients (19.3%) in Group III. Patients in Group III had significantly higher incidence of pneumonia (59.09%, p =<0.0001), meningo-encephalitis (13.6%,p=0.0146), pleural effusion (27.3%, p=0.0027), Acute renal failure (22.7%, p=0.0294) and shock (36.4%, p=<0.0001) compare to that of Group II and Group I. Duration of hospital stay (p=<0.0001) was significantly high in group III patients. Mortality rate was comparatively high in Group III (9.1%) as compared to Group II & I but not statistically significant(p=0.0959). Conclusion: Patients with marked hypoalbuminemia in scrub typhus had higher incidence of complications (Pneumonia, Meningoencephalitis, Pleural effusion, Acute renal failure, Shock), Longer hospital stay and Deaths as compared to normal albumin.
Authors and Affiliations
Arvind Kumar, Khushalaram Choudhary, R. N. Meena, O. P. Patidar
Keywords
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