Study of serum Amylase levels in type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Introduction: Pancreas is a mixed function gland with both Exocrine and endocrine portions. . Due to close proximity of the two portions disease of one part may have effect on the other part.Our study was conducted to find a possible correlation between the exocrine and endocrine functions of the pancreas by comparing serum Amylase levels in cases of Type 2 Diabetes mellitus and age matched healthy controls. Materials and Methods:The study was conducted in 75 cases of established diabetes divided into two groups Ia and Ib based on duration of diabetes <5 yrs and >5 to 10 yrs respectively. 50 age matched healthy individuals formed the control group. In both study and control groups fasting venous sample was collected and serum Amylase, Fasting Blood glucose, Serum Cholesterol and serum Triglycerides were analysed on automated analyser. Statistical analysis was done by student t test and pearsonscorrelation .Results: There is a significant decrease in Serum amylase levels in study group I when compared to control group (p<0.001). Mean Serum Amylase levels are significantly decreased in both Group I a( 56.23+6.3) and Group Ib (48.30+7.24) when compared to control group , but the decrease is more significant in Group Ib (p< 0.001) when compared to Group Ia (< 0.05).Comparison of Serum Cholesterol Between Group Ia and Group Ib showed no statistically significant alteration (p>0.05).Comparison of Serum Triglycerides between Groups Ia & Ib showed Statistical significance of higher values in Group Ib (<0.05). There is a significant Negative correlation between the S.Amylase and FBS in the Diabetic Patients (r= -0.176).This shows that poorly controlled Diabetes with high FBS had lower S.Amylase as compared to ones with a good control of Diabetes.The correlation of the S.Amylase with S. Triglycerides and S.Cholesterol in the study group was not found to be significant. (r= -0.104, r=-0.089 respectively ). Conclusion: Low S.Amylase levels are associated with Type 2 Diabetes Mellitus which clearly illustrates an impairment of pancreatic exocrine function in type 2 Diabetes Mellitus .Measurement of S.Amylase can be an additional informative parameter for the assessment of chronicity and progress of the illness as well as the response to therapy.
Authors and Affiliations
Dr. P. Kiranmai MD, Dr. V. Ratnakumari MD
Keywords
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