Study of Serum Lipid Profile in Patients with Beta-Thalassemia Major
Journal Title: International Journal of Innovative Research in Medical Science - Year 2016, Vol 1, Issue 10
Abstract
Introduction: Beta-thalassemia is an inherited blood disease characterized by inadequate production of haemoglobin, globin subunits, ineffective hematopoiesis, and increased hemolysis. Objective: The aim of the study was to examine the serum lipid profile in patients with beta-thalassemia major, and to determine the factors that affect it. Material and methods: The study comprises a total of 80 subjects between age group 4 to 14 years including patients with beta-thalassemia major (n=40) and controls (n=40). Blood samples were collected and serum was separated to be tested for serum total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and serum triglycerides was done by Erba XL-640 fully automated analyser. Results: Significant changes confirmed that lipid abnormality occur in beta-thalassaemia major patients when total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and serum triglycerides levels compared with healthy subjects. Conclusion: Our results revealed that lipid profile changed in patients with beta-thalassemia major. Many factors such as iron overload, liver injury, hormonal disturbances and aging might cause these changes.
Authors and Affiliations
Swati Choudhary, A. M. Siddiqui, H. N. Khan, A. R. Shinde
Keywords
Related Articles
- EP ID EP181561
- DOI -
- Views 62
- Downloads 0
Novel Cooling Device Enhances Autonomic Nervous System Recovery from Live Fire Training: A Pilot Study
Background: The occupation of firefighting is strenuous and dangerous. Firefighters perform demanding work while wearing heavy, insulative PPE. Thus, heat stress is a constant concern. The fire service has protocols to a...
Social Capital and the Political Economy of Recovery from Injury
Injury has long been recognized as a contributor to disability, but there is little data on how processes related to social capital, may influence the emergence of disability. This article aims to present findings from t...
The Prognostic Value of β-catenin Expression in Endometrial Cancer
Objective: To investigate the prognostic value of β-catenin expression in endometrial cancer. Methods: Immunohistochemistry was used to evaluate samples from 27 early stage and 39 advanced stage endometrial cancers. Smea...
Study of Clinical Profile, Risk Factors, Pattern of Drug Resistance and Treatment Outcome in Previously Treated Patients of Pulmonary Tuberculosis
Introduction: Tuberculosis has been a scourge of mankind from times immemorial and still an important public health problem in India and other developing countries. An estimated 3.3% of new cases and 20% of previously tr...
Evaluation of Lipid Profile in Premature, Near-term and Term Newborn Infants
Toe web space infections are the most common superficial dermatoses of the feet. They are often unnoticed and progress to cause discomfort. There is lack of enough evidence on the microbiological profile and antifungal s...