Study of Serum Malondialdehyde and Calcitriol Level in Oral Submucus Fibrosis Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: oral submucus fibrosis is a frequently seen precancerous condition of oral cavity. Chewing of areca nut is the most common etiological agent associated with it. Malondialdehyde is a toxic product formed as a result of lipid peroxidation reacts with DNA leading to its mutagenic transformation. Calcitriol is believed to have antineoplastic properties. The aim of the present study was to evaluate the levels of serum malondialdehyde and calcitriol in patients with oral submucus fibrosis. Material and methods: the study was conducted over a 4 months period and 100 patients were enrolled in the study. Patients were divided into case and control group. Each group had 50 patients. 5 ml of blood was withdrawan from anticubital vein and used for estimation of serum calcitriol and malondialdehyde. Student’s t test was used for analysis. Result: The men level of malondialdehyde amongst case group was 396.76 +/- 12.21 and that amongst control group was 250.34 +/- 9.80. This difference was statistically significant. The level of serum calcitriol amongst case group was 24.57 +/-10.21 ng/ ml and that among control group was 30.32 +/- 11.39 ng/ml. The difference between the groups was statistically not significant. Conclusion: Calcitriol is believed to have antineoplastic activity but its level does not decrease significantly amongst patients with OSMF. Malondialdehyde levels show a marked increase in OSMF patients.
Authors and Affiliations
Santosh Kumar, Sandeep Kumar, Abha Kumari
Keywords
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