Study of Serum Malondialdehyde and Calcitriol Level in Oral Submucus Fibrosis Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: oral submucus fibrosis is a frequently seen precancerous condition of oral cavity. Chewing of areca nut is the most common etiological agent associated with it. Malondialdehyde is a toxic product formed as a result of lipid peroxidation reacts with DNA leading to its mutagenic transformation. Calcitriol is believed to have antineoplastic properties. The aim of the present study was to evaluate the levels of serum malondialdehyde and calcitriol in patients with oral submucus fibrosis. Material and methods: the study was conducted over a 4 months period and 100 patients were enrolled in the study. Patients were divided into case and control group. Each group had 50 patients. 5 ml of blood was withdrawan from anticubital vein and used for estimation of serum calcitriol and malondialdehyde. Student’s t test was used for analysis. Result: The men level of malondialdehyde amongst case group was 396.76 +/- 12.21 and that amongst control group was 250.34 +/- 9.80. This difference was statistically significant. The level of serum calcitriol amongst case group was 24.57 +/-10.21 ng/ ml and that among control group was 30.32 +/- 11.39 ng/ml. The difference between the groups was statistically not significant. Conclusion: Calcitriol is believed to have antineoplastic activity but its level does not decrease significantly amongst patients with OSMF. Malondialdehyde levels show a marked increase in OSMF patients.
Authors and Affiliations
Santosh Kumar, Sandeep Kumar, Abha Kumari
Keywords
Related Articles
- EP ID EP425435
- DOI -
- Views 106
- Downloads 0
A Comparative Study of CT and MRI Findings in Aids Patients Suffering from Central Nervous System Diseases
Introduction: India has a very large burden of people living with HIV infections. All the systems in the body tend to be affected by the HIV virus, but the central nervous systems affection is involved very early in the...
Triple Malignancy Involving Breast, Ovary and Uterine Vault: A Case Report and Literature Review
Introduction: The occurrence of two or more primary malignant neoplasms in the same person is rare. We have a case report of a 45-year-old woman with triple malignancy involving breast, ovary and uterine vault being mana...
Histopathological Study of Villous Hypervascularity and Chorangiosis at Different Maternal Hemoglobin Levels
Introduction: Placenta has a remarkable reserve capacity to survive in the harmful environment, but some of the damaging factors, especially maternal anemia may have negating effects on placenta which might compromise th...
Chemotherapy Improves Quality of Life and Prolongs Survival in Patients of Lung Cancer
Lung cancer is the most frequently diagnosed cancer and the foremost cause of cancer-related deaths. Particularly, lung cancer has an estimated incidence of 1.6 million new cases every year. Despite the various advances...
Prognostication Studies of Prostate Cancer in Black Africa: Findings from Calabar, South-South, Nigeria
Introduction: Prostate cancer is the commonest cancer in males in Nigeria, a country with the largest concentration of indigenous black patients worldwide. The disease has variable clinical behavior but is noted to have...