Study of serum malonyldialdehyde (marker of lipid peroxidation) and paraoxonase-1 in chronic obstructive pulmonary disease patients with alterations in their lipid profile in Muzaffarnagar region
Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 5
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a term for a group of diseases that affects lung. Objective: Objective of our study was to evaluate paraoxonase-1 (PON1) activity, malonyldialdehyde (MDA) and lipid profile in COPD patients and healthy control. Materials and Methods: Serum MDA and PON1 level were measured by Kei Satoh and arylesterase method, where lipid profile was determined by biochemistry fully autoanalyzer (CPC TurboChem 100). Results: The mean level of (marker of oxidative stress malonyldialdehyde) MDA was profoundly higher in cases (P < 0.0001) as compared to control group. The antioxidant enzyme PON1 were lower (P < 0.0001) in cases than control. The mean levels of total cholesterol, triglyceride, low-density lipoprotein (LDL), very LDL were significantly higher in cases as compared to control group. The mean level of high-density lipoprotein was lower in COPD patients as compared to control group. Conclusion: Our results concluded that the reduction in PON1 activity could reflect oxidative changes of enzyme free cysteine residues.
Authors and Affiliations
Shikha Rawat, Manisha Arora, Imran Mustafa, Sameer Anand, Sudeep Kumar, Roshan Kumar Mahat, Manju Sharma
Keywords
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- EP ID EP316284
- DOI 10.5455/ijmsph.2017.1165616122016
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