Study of Serum Prostate Specific Antigen (PSA) Levels in Patients of Benign Enlargement of Prostate and Prostatic Cancer
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 9, Issue 1
Abstract
Prostate specific antigen (PSA), neutral serine protease secreted exclusively by prostatic epithelial cells, has a number of applications in the management of men with prostatic carcinoma. While it is widely recognized that elevated PSA correlates with the presence of carcinoma, little data exist regarding the use of PSA as the initial test in the early detection of prostatic cancer Prostate-specific antigen (PSA) is a protein produced by the prostate and this protein may be elevated for several reasons, including prostatitis, benign prostatic hypertrophy and cancer. The value of the PSA test varies when used for screening, diagnosis, prognosis and as indicator of recurrence of prostate cancer. AIMS and Objectives: To study levels of Serum PSA in patients of Benign prostatic hypertrophy and prostatic carcinoma and comparing them with normal healthy individuals above 55 years of age. Material and Methods: The study was performed on 100 consecutive male patients (mean age 68 ± 10.8 years SD) comprising of 80 patients with benign disease (80%) and 20 prostate carcinoma patients (20%), who had histologically proven prostate cancer. Patients with total PSA between 2-25 ng/ml were included in the study. 30 normal healthy males with age 55 ± 10 years, served as control. Serum total PSA were analyzed using CLIA method.The mean total PSA in normal healthy control subjects was 1.72 ± 1.06 ng/ml. It was increased significantly in diseased condition. Its mean concentration in carcinoma patients was 12.6 ± 5.3 ng/ml and in benign patients it was 6.3 ± 4.6 ng/ml. Conclusions: Markedly increased PSA levels in serum suggests a cancer. This information may aid patients and clinicians in management of prostate cancer, such as selecting patients for watchful waiting. However, more research is needed to determine the performance characteristics of PSA in clinical practice. It is recommended that the use of PSA and Digital Rectal Examination in combination is important as a diagnostic procedure for the early detection of prostate cancer.
Authors and Affiliations
Dhananjay Vasantrao Bhale
Keywords
Related Articles
- EP ID EP88453
- DOI -
- Views 167
- Downloads 0
Histopathological study of tumours of adipose tissue
Background: Tumours of adipose tissue form one of the largest single groups of soft tissue tumours. The benign, subcutaneous lipoma is the most common soft tissue neoplasm in adults, liposarcoma being the most common pri...
Investigation of a Hepatitis A outbreak in Panachkkad PHC area of Kottayam district Kerala by case control design
Background: Viral Hepatitis (HAV) continues to be a major public health problem in India and is hyper-endemic for HAV infection. Early investigation of an epidemic of Hepatitis A will go a long way in containing the epid...
Utility of Leukocyte Esterase Dipstick test in bed side diagnosis of Spontaneous Bacterial Peritonitis in Patients of Cirrhosis of Liver with Ascites
Background: Spontaneous bacterial peritonitis (SBP) is commonest and severe complication of decompensated cirrhosis. SBP is defined as the infection of ascitic fluid (AF) in the absence of a contiguous source of infectio...
A pilot study: Development of a reference spatiotemporal gait data set for Indian subjects
Interpretation of pathological gait has, for decades, offered insight into amputee anomalies and diseases such as cerebral palsy. Gait analysis has been actively used at the Bhagwan Mahaveer Viklang Sahatya Samiti for su...
Fertility pattern among married female employees at Government Medical College and Hospital and Government Ayurvedic College and Hospital, Nanded
The regulation of fertility through intervention requires knowledge of level of fertility. The present study was carried out among married female employees working at Government Medical College and Hospital, and at Gover...