Study of Spot Urinary Protein/Creatinine Ratio as an Alternative for 24-Hour Urinary Protein in Pre-Eclampsia in and around Chitradurga
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 4
Abstract
Pre-eclampsia is defined as new onset of elevated blood pressure and proteinuria after 20 weeks of gestation. Urinary protein-creatinine ratio has been used to evaluate proteinuria in pre-eclampsia. The presence of proteinuria is seen as a possible indication of many complications in pregnancy and it remains central to the diagnosis of pre-eclampsia. It has both diagnostic and prognostic implications. 24 Hours Urine protein measurement is a standard method for the detection of proteinuria but it is time-consuming, needs more assistance from paramedical staff or nonmedical persons, the results are cumbersome if done not properly and need 24 hours’ time. As an alternative, Spot sampling for a urine protein to creatinine (P/C) ratio has been investigated to determine the diagnostic accuracy of the protein to creatinine ratio (P/C) for the detection of remarkable proteinuria. A case control comparative study was done with women having pre-eclampsia and normal pregnant women admitted in Gynecology department of Basaveshwara Medical College Hospital & RC, Chitradurga according to the criteria. There was a good positive correlation between spot Urinary Protein /Creatinine Ratio and 24-hour Urinary protein excretion, with a correlation coefficient (r) of 0.980. The best cut-off which gave the maximum area under the curve was 0.14 for 300 mg, 0.36 for 1000 mg, 0.63 for 2000 mg, 0.76 for 3000 mg, 1.06 for 4000 mg and 1.40 for 5000 mg per 24h Urinary Protein excretion. A Urinary protein/creatinine ratio above 0.63 strongly predicts significant 24 hour urinary protein for more than 1 gram.
Authors and Affiliations
Dr. Gaurang K. Anandpara, Dr. Aruna Sharma, Dr. Suraj Khandhedia
Keywords
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