Study of the Effect of Panax Ginseng versus Gliclazide on Hyperglycaemia Induced by Dexamethasone in Experimental Animals
Journal Title: Sultan Qaboos University Medical Journal - Year 2009, Vol 9, Issue 1
Abstract
To study the effect of panax ginseng versus gliclazide on hyperglycaemia induced by dexamethasone in experimental animals. Methods: Te current study was conducted in the Department of Pharmacology, University of Science & Technology, Sana’a, Yemen. Twenty-four rabbits were divided to 4 groups. Tree of them were administered oral doses of dexamethasone (0 mg/kg) for 4 days, one group was kept as a control. Ginseng at dose (200 mg/kg) and gliclazide (80 mg/kg) were administered to rabbits with dexamethasone-induced hyperglycaemia. Results: Te effects of ginseng and gliclazide on fasting blood sugar (FBS) and body weight after continuous administration of dexamethasone (0 mg/kg) were measured. Oral administration of ginseng (200mg/kg) for 2 weeks produced significant (p <0.05) reduction in FBS from 25.33±27.67 mg/dl in the dexamethasone group to 54.7±2.8mg/dl in the ginseng treated group. In addition, ginseng produced significant (p <0.05) reduction in body weight. Conclusion: Tere was a significant difference between ginseng and gliclazide in reduction of FBS and body weight. From these results, it is suggested that ginseng could be used in obese diabetic patients or those suffering from insulin resistance as it reduces body weight.
Authors and Affiliations
Doa’a A Ibrahim| Department of Pharmacology, University of Science & Technology, Sana’a, Yemen
Keywords
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