Study of the Effect of Panax Ginseng versus Gliclazide on Hyperglycaemia Induced by Dexamethasone in Experimental Animals
Journal Title: Sultan Qaboos University Medical Journal - Year 2009, Vol 9, Issue 1
Abstract
To study the effect of panax ginseng versus gliclazide on hyperglycaemia induced by dexamethasone in experimental animals. Methods: Te current study was conducted in the Department of Pharmacology, University of Science & Technology, Sana’a, Yemen. Twenty-four rabbits were divided to 4 groups. Tree of them were administered oral doses of dexamethasone (0 mg/kg) for 4 days, one group was kept as a control. Ginseng at dose (200 mg/kg) and gliclazide (80 mg/kg) were administered to rabbits with dexamethasone-induced hyperglycaemia. Results: Te effects of ginseng and gliclazide on fasting blood sugar (FBS) and body weight after continuous administration of dexamethasone (0 mg/kg) were measured. Oral administration of ginseng (200mg/kg) for 2 weeks produced significant (p <0.05) reduction in FBS from 25.33±27.67 mg/dl in the dexamethasone group to 54.7±2.8mg/dl in the ginseng treated group. In addition, ginseng produced significant (p <0.05) reduction in body weight. Conclusion: Tere was a significant difference between ginseng and gliclazide in reduction of FBS and body weight. From these results, it is suggested that ginseng could be used in obese diabetic patients or those suffering from insulin resistance as it reduces body weight.
Authors and Affiliations
Doa’a A Ibrahim| Department of Pharmacology, University of Science & Technology, Sana’a, Yemen
Keywords
Related Articles
- EP ID EP13856
- DOI -
- Views 320
- Downloads 12
Breastfeeding Trends and Determinants Implications and recommendations for Gulf Cooperation Council countries
Optimal breastfeeding practices entail the early initiation of breastfeeding soon after delivery of the baby, exclusive breastfeeding for the frst six months of life and the continuation of breastfeeding complemented b...
Chronic Umbilical Discharge An unusual presentation of endometriosis
Umbilical endometriosis is an important differential diagnosis of any umbilical lesion. A 35-yearold type 2 diabetic woman presented with intermittent umbilical discharge which failed to respond to various antibiotics....
Paliperidone Palmitate-Induced Delirium in an Adolescent with Schizophrenia Case report
Schizophrenia is a serious long-term mental disorder which usually presents in adolescence or early adulthood. However, poor adherence to oral antipsychotics can lead to relapse and rehospitalisation. We report an adol...
Caesarean sections at Sultan Qaboos University Hospital: A three year review
Objective: To review the caesarean sections (C/S) performed at Sultan Qaboos University Hospital (SQUH), Muscat, Oman, over a period of three years. Method: The records of 727 patients who underwent C/S at SQUH during t...
Reflections on the Academic Accreditation of the MD Programme of the College of Medicine & Health Sciences, Sultan Qaboos University, Oman