Study of the influence of Hydrophillic polymers and Citric acid on Bi-layered floating tablets of Diltiazem hydrochloride
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
In the present study an attempt was made to study the effect of formulation variables on bilayered floating tablet of Diltiazem hydrochloride. Immediate release layer was formulated by using various super disintegrants such as sodium starch glycolate, cross carmellose sodium, crospovidone and sustained release layer was formulated with different grades of hydrophilic polymers like HPMCK4M, HPMCE5 and HPMCK100M by wet granulation method. The influence of polymer and citric acid concentrations were also investigated. The prepared tablets were characterized and rate of drug release from an immediate release layer was 99.9% were found at the end of 20 minutes followed by sustained the drug release for 12hrs from sustained release layer. The dissolution data were fitted into zero order, first order, Higuchi and Peppas equations. Results revealed that the drug release from the formulation F20 followed zero order kinetics and exhibited Peppas transport mechanism.
Authors and Affiliations
Venkateswara Rao T, Bhadramma N, Raghukiran CVS, Madubabu K
Keywords
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