Study Of The Role Of Septin12 Gene Expression Of Human Spermatozoa On Infertility
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Septins belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, such as membrane compartmentalization, vesicular traficking, mitosis,and cytoskeletal remodeling.One family member, septin12, is expressed specifically in the testis. The aim of the present study was to determine the association between septin12 gene expression by RT-PCR and fertilization ability of human spermatozoa . The present study included 80 semen samples that were obtained from men attending the andrology Outpatient Clinic, Mansoura University Hospital, Mansoura, Egypt and grouped into four group: Normozoospermia (n=20), Asthenozoospermia (n=20), Astheno-Teratozoospermia (n=20), Oligo-AsthenoTeratozoospermia (n=20).The current study showed a statistically significant highly positive correlation in Septin12 gene expression with sperm concentration, grade A motility, grade (A+B) motility, velocity, linear velocity, linearity index, normal morphology . However, it shows significant negative correlation with WBCs.Septin12 had highly significant negative correlation with FSH, however it had moderately significant positive correlation with testosterone.It also had highly significant positive correlation with DHEA-S. In conclusio, SEPTIN12 gene expression provides clinical useful information for the diagnosis of male infertility. It might be a marker for discrimination between fertile and infertile patients
Authors and Affiliations
Amal K. Seleem, Adel Abd El-Kader Zalata¹, Mostafa Aly Hussien, Faeza EL Dahtory, Dina Aly Abdelaziz*
Keywords
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