Study of tubal intraepithelial neoplasia (TIN) in various ovarian tumours.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Serous tubal intraepithelial carcinoma (STIC), an early lesion limited to the epithelium of the fallopian tube and firstly identified from specimen obtained by prophylactic salpingo-oophorectomy. Histopathological features of STIC include a variable combination of epithelial stratification, loss of cellular polarity, irregular luminal surface, pleomorphism,loss of cilia,nuclear rounding, increased nucleo-cytoplasmic ratio, prominent nucleoli and mitotic figures. Recently described lesions overexpressing p53 in the distal tubes of mutation carriers, and non carriers, have been proposed as histological precursors of high grade serous carcinoma (HGSC). A careful histological examination of ovaries and fallopian tubes prophylactically resected from BRCA1/BRCA2 mutation carriers has provided clues to the existence of cancer precursor lesions in women genetically predisposed to high grade serous carcinoma, and they have been identified not in the ovary, but in the distal tubal epithelium. Present study was undertaken to observe the histological changes in the fallopian tubal epithelium in various ovarian tumours.
Authors and Affiliations
Kalpana Bothale
Keywords
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- EP ID EP421546
- DOI 10.9790/0853-1711120811.
- Views 62
- Downloads 0
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