Study of Vitamin B12 Levels in Patients of Sickle Cell Disease in a Tertiary Care Hospital, Jharkhand
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Introduction: Cobalamine is required mainly for two important conversion reactions in the body1.for methymalonylcoA isomerization, 2.for methylation of homocysteine. Deficiency of these two reactions in the body has widespread implications. While the deficiency of folic acid in sickle cell anemia has been comprehensively studied, vitamin b12 has been widely overlooked leading to undefined morbidity patterns Material and methods: seventy patients with sickle cell disease were selected for the study.50 were males and 20 females. Complete blood counts, hemograms, vitamin b12 and folic acid levels were obtained and compared with 100 controls. Patients were devided into two groups 1. Group A-patients with low vitamin B12 levels<160 2. Group B-patients with low-normal vitaminB12 levels>160 Results: vitamin b12 levels in control group was between 146-860mg/dl(319+_160)Vitamin b12 in study group A was (70.4+-30.6), Vitamin B12 in study group B was(215+_68.6)mean value 153.4. The results were statistically significant difference placed at p<=0.03 Conclusions: A High index of suspicion has to be maintained for Vitamin B12 deficiency in sickle cell anemia patients. Supplementation and monitoring is essential to prevent disease.
Authors and Affiliations
Dr. Soni Narayan, Dr. Balaram Jha, Dr. Sanjay Kumar, Dr. Subhashish Sirkar
Keywords
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- EP ID EP574589
- DOI 10.9790/0853-1804142835.
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