Study of Zinc Level in Egyptian Cirrhotic Patients with Different Stages of Liver Cirrhosis
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 6
Abstract
Background: Liver cirrhosis is a widespread disease differentiated by spread liver fibrosis and formation of nodules. During the last years, concentrations of minerals in patients with chronic hepatic disease have been investigated extensively. In fact, liver is responsible for regulation of the metabolic pathway and trace elements (TE) transport, and their bioavailability, distribution in tissue and consequent toxicity. , for magnesium, manganese, chromium, selenium and zinc in other types of chronic hepatic disease. The alterations of these trace elements were related mostly to malnutrition in hepatic disease. Zinc is one of the most important trace elements in the human body. Zinc is responsible for activation of about 300 different metallo-enzymes and metal-activated enzymes in vivo and is essential for the metabolism of nucleic acids and proteins. Methods: The work was carried out on a cluster of (60) patients with liver cirrhosis attending outpatient clinic and those admitted at the internal medicine inpatients wards. They were calcified into three groups A, B & C according to child calcification, 20 patients in each group. Full history, clinical examination and investigation were done, estimation of serum Zinc level. Results: Serum zinc level decreases with cirrhosis especially with advanced cases and have direct relation with the degree of severity of liver disease and its complications as hepatic encephalopathy, ascites, hypoalbuminemia and malnutrition. Conclusion: Zinc, is a helping element of the urea cycle enzymes, can be decreased in patients with cirrhosis, particularly if joined with malnutrition.
Authors and Affiliations
Khalil Ali Khalil, Fadia Mostafa Attia, Fawzy Attia Khalil, Ahmed Hamdey EL-Tabey, Hany Haron, Hesham Drwesh
Keywords
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- EP ID EP532468
- DOI 10.21276/ijmrp.2018.4.6.007
- Views 93
- Downloads 0
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