STUDY ON CLINICAL PROFILE AND CAUSES OF HYPOKALAEMIC PERIODIC PARALYSIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 50
Abstract
BACKGROUND Hypokalaemic Periodic Paralysis (HPP) is a Channelopathy which affects the musculoskeletal, nervous, endocrine or metabolic systems and is characterised by episodic skeletal muscular weakness and paralysis in the setting of hypokalaemia. It is classified into primary and secondary types. Based on the clinical studies, the most common cause of HPP in India is Primary Familial Hypokalaemic Periodic Paralysis (FHPP). Identifying the reversible causes of HPP will help in optimising management protocols with specific therapy. MATERIALS AND METHODS In this study, we analysed the clinical profile and causes of HPP in 50 patients with the clinical background of episodic muscular weakness due to Hypokalaemia alone admitted in the General Medicine and Neurology wards at M.G.M. Govt. Hospital, Tiruchirappalli, with age from 17 to 68 years of both males and females over one-year period. The mean duration of illness before presentation was 28 months (range 5 to 70 months) and they had a mean of 4 episodes of HPP (median 3, range 1 to 6 episodes). The data of all patients who presented with HPP were analysed. RESULTS In our study of the total 50 patients, 43 (86%) were males and 7 (14%) were females. We found 96% (48) patients with primary FHPP and 4% (2) patients with secondary HPP, of which 2% (1) patients with Gitelman Syndrome (G.S.) and another 2% (1) patients with Distal Renal Tubular Acidosis (RTA). CONCLUSION From this study, the patients presented with sudden onset of paralysis and markedly low serum (Sr.) potassium (K+) levels, typical of HPP. Its symptoms resolved completely and quickly following correct treatment depending upon the clinical status and causes. HPP can be fatal if the diagnosis and treatment was not done at appropriate time.
Authors and Affiliations
Natarajan Ramesh, Sappani Kasipandian, Meenakshi Sundaram Rajasekaran
Keywords
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- EP ID EP219657
- DOI 10.14260/Jemds/2017/834
- Views 66
- Downloads 0
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