Study On Drug Solubilisation and Synergism Using Prominently Used Non Ionic Surfactants and Sodium Lauryl Sulphate
Journal Title: Galore International Journal of Health Sciences and Research - Year 2018, Vol 3, Issue 4
Abstract
In the present study amount of Cefixime and amount of Metronidazole solubilised using PEG 6 K, PEG 20 K, PVP K 30, Brij 30 and Sodium lauryl sulphate alone and in combinations was investigated. Study results showed that drug amount solubilised by single surfactant was higher than water for both drugs and values were noticeable for Brij 30 and Sodium lauryl sulphate. Regarding drug amount solubilised using surfactant combination results showed synergistic effects and the effect was prominent when Brij 30 and Sodium lauryl sulphate were present in combination.
Authors and Affiliations
Md. Bodiuzzaman Rabbi
Keywords
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