Study on Follow-Up of Ulcerative Colitis Patients on Sulfasalazine At Our Hospital – Retrospectivecohort Study.

Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9

Abstract

INTRODUCTION: Ulcerative colitis is a chronic inflammatory disease of the colon of unclear etiology with an increasing incidence in India. Typical symptoms are diarrhoea, rectal bleeding, abdominal pain and fever. Sulfasalazine is effective well tolerated first line therapy for mild, moderate and severe ulcerative colitis. AIM: To Study the Clinical Remission in Ulcerative Colitis patients on Sulfasalazine at our hospital. METHODS: Retrospective data of70 Patients with Ulcerative colitis on sulfasalazine, diagnosed by Clinical, Endoscopic and Histopathologic evaluation, from year 2014-2017 at our hospital were included in the study and patients with other comorbidity, non-compliance to treatment,on azathioprine or biologicals were excluded. The primary end point was Clinical remission based on Mayo score. RESULTS: Retrospective data from 70 patients with ulcerative colitis diagnosed at our hospital from year 2014-2017 were collected. Out of 70 patients(Male=43,female=27) with age group of 24-56 years and mean age of 40 years with average symptom duration of 6 months prior to our hospital visit. All were reassessed during follow up at our hospital and classified into Mild UC group (n=23), Moderate UC group (n=31) and Severe UC group (n=16) using Truelove and Witts classification. Mild UC patients were responded in the form reduction in stool frequency from 3-4/day with blood streak to normal stool frequency with no rectal bleeding in 6 months of treatment with sulfasalazine and no exacerbations. Among Moderate UC patients 26 responded well in the form of reduction in stool frequency from 4-5/day with obvious blood to 1-2/day with no blood in stool, with 6 month of sulfasalazine and initial steroid for 10 days, 4 lost follow up, 1 was steroid dependent. Among severe UC 9 responded well from stool frequency of >6/day with frank blood to 1-2/day with occasional blood streak in stool, with 6 months of sulfasalazine and initial steroid for 10 days,03 were steroid dependent, three were refractory to conventional treatment with development of mild dysplasia on histopathology in 2 among 3 and 1 required emergency colectomy for Toxic mega colon. Meanwhile both moderate and severe UC patients developed recurrent exacerbations requiring steroid for duration of 10 days, reasons for exacerbation were Infections, change in environment (eg: Travel). CONCLUSIONS: Sulfasalazine still represents effective and well-tolerated first-line therapy for mild, moderate and severe ulcerative colitis as well as for the long-term maintenance treatment in the era of Biologicals and other Immunosuppressant.

Authors and Affiliations

Dr. S. B. Malipatil, Dr. R. Balamurali

Keywords

.

Related Articles

Clinical outcomes following enhanced respiratory support in ILD Patients with acute Respiratory failure

The outlook for patients with ILD presenting to hospital needing respiratory support is poor be it non-invasive ventilation or mechanical ventilation. Based on the available evidence it is difficult to determine a clear...

Adverse Reactions In Whole Blood Donors: A Population Based Statistical-epidemiological Study

Background: Human blood is the most precious and essential element of human life. Safe and adequate blood supply is a big challenge in developing countries like India. Voluntary blood donors tolerate blood donation very...

Sporadic Outbreaks of Diphtheria: A Three Year Study from a Tertiary Care Centre of Northeast India.

Diphtheria is an acute toxin mediated contagious febrile illness, predominantly in children, caused by the locally invasive Gram positive bacillus Corynebacterium diphtheriae. In developing countries, with increasing cov...

Pulse Oximetry Screening toDetect Cyanotic Congenital Heart Disease inSick Neonates inaNeonatal Intensive Care Unit

Objective: To evaluate pulse oximetry for detection of congenital cyanotic heart disease in sick neonates using echocardiography as gold standard. Methods: Pulse oximetry readings were taken at admission from 500 neonate...

A Comparative Study of External and Endoscopic Endonasal Dacryosystorhinostomy

Purpose: To compare the results of Endoscopic Endonasal DCR with External DCR. Methods: All patients with the symptom of epiphora from period between June,2016 to june , 2018 were included Results: Of total 60, 30 operat...

Download PDF file
  • EP ID EP395473
  • DOI 10.9790/0853-1709104046.
  • Views 69
  • Downloads 0

How To Cite

Dr. S. B. Malipatil, Dr. R. Balamurali (2018). Study on Follow-Up of Ulcerative Colitis Patients on Sulfasalazine At Our Hospital – Retrospectivecohort Study.. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), 17(9), 40-46. https://europub.co.uk/articles/-A-395473