Study on impact of patient related variables on CD4 count and opportunistic infections in HIV seropositives

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Study on impact of patient related variables on CD4 count and opportunistic infections in HIV seropositives

Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2018, Vol 6, Issue 1

Abstract

Background Opportunistic infections are the hallmark manifestations of AIDS. To decrease the incidence of OI’s in PLHIV, there is a need to study the impact of all relevant factors which may be a key for the development of OI’s. Aim To study the impact of patient related variables on CD4 count and opportunistic infections in people living with HIV. Methods and methodology A Prospective Observational study was carried out at ART center. HIV patients who met inclusion criteria were informed consented and included in the study and relevant data was collected in a prior designed data collection form. Results A total of 214 patients having OI’s were included among which 55.1% (n=118) were women and 44.9% (n= 96) were men. Most of the OI’s occurred in the age group of 31- 40 yrs. (n=85; 39.17%) and when CD4 count was between 100-350 cells/mm3. TB was the most common OI (n=115; 50%) followed by candidiasis (n= 110; 47.8%). When BMI was correlated with CD4; it revealed that underweight was predominant (n=62; 79.49%) when CD4 count was < 350 cells/mm3. Grade II anemia was most common (n=97; 49.24%) and most of the patients with OI’s belong to upper lower class (n=179; 83.64%) according to KSES. Risk grading using JDPV scale reveals 107 (50%) patients fall under high risk category and 64 (29.3%) , 4 (1.87%) are with moderate and high risk respectively. Conclusion This study reveals that there is a positive relationship between BMI and CD4 count and it also shows that the incidence of OIs is influenced by multiple factors which should be considered to provide appropriate care to the patient.

Authors and Affiliations

Divya Yedluri

Keywords

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