Study on intra and intreobserver variability of prostate cancer grading
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 4
Abstract
<b>Introduction.</b> Adenocarcinoma of the prostate is one of the most frequent cancer in man. Clinical stage and grade based on Gleason score scale are main circumstances according to which a method of treatment is chosen. Gleason score grading remains subjective and is a reason for intra and intrerobserver variability.<br><b>Material and methods.</b> Accidentally chosen histopatological material of patients treated with prostate cancer (<sup>TRUS</sup>coreBx and specimens after RP) between 2001 and 2008 was analyzed by two independent and experienced uropathologists.<br><b>Results.</b> Lack of agreement in Gl.s. between first and second estimation of the same pathologist was found in 83 (80.5%) of core biopsies and in 72 (69.1%) postoperative specimens. In comparison between second estimation of first pathologist and second pathologist disagreement was found in 57 (58.35) core biopsies and in 62 (63.4%) specimens after surgery.<br><b>Conclusions. </b>Intra and interobserver variability in Gleason score grading of prostate cancer are high. To reach the most precise diagnosis urologist should closely cooperate with pathologists. Having in mind discrepancies in Gleason score grading should know intraobserver variability of pathologist they cooperate with.
Authors and Affiliations
Łukasz Nyk, Tomasz Dzik, Maciej Wysocki, Elza Modzelewska, Jakub Dobruch, Piotr Chłosta, Andrzej Borówka
Keywords
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