STUDYING THE FREQUENCY DISTRIBUTION OF CHROMOSOMAL ABNORMALITIES AND ITS RELATIONSHIP WITH DRIVER SOMATIC MUTIONS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA
Journal Title: International scientific journal Science and Innovation - Year 2024, Vol 3, Issue 9
Abstract
The given article presents the peripheral blood of 145 patients with AML, who were in inpatient treatment at the Republican Specialized Scientific and Practical Medical Center of Hematology of the Ministry of Health of the Republic of Uzbekistan served as the material for molecular genetic research. Clinical and laboratory studies were performed at the Republican Specialized Scientific and Practical Medical Center of Hematology of the Ministry of Health of the Republic of Uzbekistan. The study demonstrated a significantly higher frequency of NPM1 mutation distribution in patients with normal karyotypes compared to patients with chromosomal disorders (35.3% versus 9.4% with χ2=7.0; OR=0.2; p=0.01; 95% CI: 0.06-0.65). Statistical processing of the results was performed using the standard Open Epi V.9.2 application software package.
Authors and Affiliations
Musashaykhova Sh. M.
Keywords
Related Articles
- EP ID EP748017
- DOI 10.5281/zenodo.13834769
- Views 43
- Downloads 0
CULTURAL RELATIONS BETWEEN UZBEKISTAN AND TURKEY
This article explores the historical, cultural and modern ties between the two countries. The article examines the common Turkic heritage, Islamic influence and hospitality as common cultural features. The article also d...
CREATION OF COMPLEX PROCESSING TECHNOLOGY FOR INDUSTRIAL WASTE FROM SODA ASH PRODUCTION
Soda ash, a critical component in industries such as glassmaking, chemicals, and detergents, generates significant industrial waste during production. These wastes' improper disposal and management contribute to environm...
HOW DOES OBSESSIVE-COMPULSIVE DISORDER MANIFEST ITSELF?
This article examines the causes of obsessive-compulsive disorder in people of different ages, and what factors trigger its occurrence. It also shows how it occurs in teenagers and its symptoms.
PSYCHOLOGICAL PROBLEMS AND SOCIAL ATTITUDES OF YOUNG PEOPLE GROWING UP IN INCOMPLETE FAMILIES
The article covers the role and social problems of the dysfunctional family in society. The problems encountered in the psychology of children under the age of majority in a dysfunctional family and their classification...
ESTABLISHING A HEALTHY LIFESTYLE - PATH TO STRENGTHENING HEALTH
A healthy lifestyle (HL) is a combination of forms and ways of daily cultural activities based on cultural norms, values, and the meanings of one's actions, which enhance the body's adaptive capacities. HL ensures harmon...