Sub Acute Toxicity Studies of Punicaflavone from the Methanolic Flower Extract of Punicagranatum(LINN.) in Rats
Journal Title: Saudi Journal of Medicine - Year 2018, Vol 3, Issue 6
Abstract
Abstract:In the present study, the isolated compound Punicaflavone(PF) from the methanolic flower extract of Punicagranatum (Linn.) was subjected to toxicity assessment in Wistar albino rats. Sub-acute toxicity studies were carried out by oral administration of the PF from Punicagranatum (Linn.) for aperiod of 28 days at different dose levels of 50, 100 and 200mg/kg body weight. No major changes in body and organ weight, behavioural, haematology and histology were observed at the end of 28 days of daily oral administration. Biochemical parameters such as the levels of Glucose,Protein, Urea and Creatinine in serum were found to be well within the normal limits. Histopathological examination of the major vital organs (heart, liver and kidney) revealed no significant pathological alterations in the treated group of rats. The sub-acute toxicity studies of the PF showed no mortality and no symptoms of toxicity or behavioral changes at the maximum dose (1000mg/kg). The results indicate that the PF is safe up to a dose of 1000 mg/kg. Keywords:Punicagranatum(Linn.), Methanol extract, Punicaflavone and Sub acute toxicity.
Authors and Affiliations
R. Nalini
Keywords
Related Articles
- EP ID EP399700
- DOI -
- Views 69
- Downloads 0
Clinical Evaluation of Brachytherapy: A Light of Hope for Cervical Cancer Patients
Abstract: The objective of this study is to exploration the part of brachytherapy in treating cervical cancer. Cervical cancer is cancer of the cervix — the lower part of the uterus, which opens into the vagina. Cervical...
Tolosa-Hunt Syndrome: A rare cause for an isolated ocular nerve palsy in an elderly male
Abstract: Tolosa-Hunt syndrome (THS) is essentially a clinical diagnosis of exclusion; painful ophthalmoplegia caused by nonspecific inflammation of the cavernous sinus or superior orbital fissure. We reported a 70 year...
Pattern and Early Treatment Outcome of Abdominal Injuries in Hospital Pakar Sultanah Fatimah Muar
Abstract:Abdominal trauma is responsible for 10% of all the traumatic deaths. With progressing technologies and civilization, the profile and pattern of abdominal trauma is changing. This study was conducted to look int...
Lipid Profiles in Chronic Renal Failure
Abstract:Chronic renal failure is increasingly health problem all around the world with a high burden of mortality and cardio vascular morbidity rate. The study is mainly directed to establish lipid profile in chronic re...
Design Method of Stroke Research Based On Complex Network
In order to understand cerebral vascular disease better in stroke, we collect the reasons of prevention and control so as to find the methods. Complex network is a new tool to find the inner factors of a real system that...