Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice
Journal Title: Toxicology and Forensic Medicine – Open Journal - Year 2016, Vol 1, Issue 2
Abstract
Background: Calotropis gigantea of family Asclepiadaceae, is traditionally used in ayurveda for its anti-helminthic, anti-pyretic, and anti-malarial activities. The present study was designed to investigate the sub-acute toxic effects of ethanol and methanol extract of Calotropis gigantea latex in mouse model using haematology, serum biochemistry and histopathological changes as toxicity indices. Methods: In the sub-acute 28-day toxicity study, ethanol and methanol extract of Calotropis gigantea latex were administered intraperitoneally at the dose levels of 50, 100, 200, 500, 1000 and 2000 mg/kg body wt./day. Results: Significant (p>0.05) difference were not observed in relative organ weights and haematological, hepatic and renal biomarkers up to the dose level of 500 mg/kg body wt./day for 28 days except blood glucose and serum glutamate pyruvate transaminase (SGPT) in comparison to the control group. No significant toxicity was seen up to the dose level of 1000 mg/kg body wt./day for 28 days in case of blood glucose and SGPT. Conclusion: The findings suggest that Calotropis gigantea latex extracts do not cause subacute toxicity up to the level of 1000 mg/kg body wt./day for 28 days and may be considered as phytomedicinal therapeutic agents.
Authors and Affiliations
Sujata Maiti Choudhury
Keywords
Related Articles
- EP ID EP551001
- DOI 10.17140/TFMOJ-1-109
- Views 149
- Downloads 0
Mycotoxin MT81 and Its Benzoylated Derivative Exhibit Potential Antisteroidogenic Activities In Prepubertal Female Wistar Rat
MT81, a mycotoxin (polyhydroxyanthraquinone, Molecular formula C22 H18 O7) was isolated and identified from Penicillium nigricans. It is highly toxic (LD50 value is 35.1 mg/kg body weight) and shows antimicrobial, antile...
The Effect of DNA Evidence on Incidence of Property Crime Arrests
Background: With a high volume of incoming cases and ever-present backlogs, forensic laboratories are often limited with the funding and resources necessary to test every evidence item waiting to be processed.1 Properly...
A Case of Star Fruit Diet
A 47-year-old obese woman is brought to the emergency room of the local hospital with generalized seizures, impaired consciousness and hiccupping; according to her relatives she never experienced such symptoms in the pas...
In Vitro Cytotoxicity and Antioxidative Potential of Nostoc Microscopicum (Nostocales, Cyanobacteria)
Many cyanobacterial species (cyanoprokaryotes, blue-green algae) are potent producers of various secondary metabolites with low molecular weight and diverse biological activities (antitumor, antimycotic, antiviral, antim...
Hepatotoxic-Microcystins in Two Drinking Water Reservoirs in the Central Region of Ghana
Background: Microcystins are cyclic peptides containing seven amino acids with the condensation of two terminal amino acids of the linear peptide to form a cyclic compound. The cyclic nature of microcystins suggests that...