Subcutaneous pharmacokinetic interaction of tulathromycin With flunixin meglumine in goats

Journal Title: Journal of Veterinary Medical Research - Year 2016, Vol 23, Issue 2

Abstract

The pharmacokinetic aspects of tulathromycin(2.5 mg/kg) administered alone and in combination with flunixin meglumine (2.2 mg/kg) after a single subcutaneous (SC) administration, werestudied in clinically healthy goats. The animals were divided into two groups: the 1st group was given tulathromycin alone and the 2nd group was given tulathromycin concurrently with flunixin meglumine. Serum concentrations of tulathromycin were determined using microbiological assay method. Tulathromycin was rapidly absorbed with a half-life of absorption (t(0.5)ab) of 0.54 h and the peak plasma concentration (Cmax) was 3.7ug/ml was attained after 0.98 h (Tmax). Flunixin significantly altered the pharmacokinetics of tulathromycin by increasing its absorption and delay its elimination from body where t0.5(ab)were 0.54 and0.34 h and the elimination half-lives (t0.5(el)) were 1.35 and 1.8 h, for alone and combination groups, respectively. Significant decreases (39.8%) in the area under the curve (AUC) and (22.6%) in the elimination rate constant (Kel) from the central compartment were found following coadministration with flunixin compared with administration of tulathromycin alone. It was concluded that the combination of tulathromycin and flunixin negatively altered the kinetics of tulathromycin.

Authors and Affiliations

M. Adam, M. A. Tohamy, S. E. El-Sadek, Abeer M. Radi

Keywords

Related Articles

Some virulence factors of Escherichia coli isolated from diarrheic calves

Escherichia coliare the most common cause of diarrhea in calves. Diarrhea in calvesremains one of the most important problems faced by livestock, causing great economic losses. Some strains ofE. coli characterized by the...

Antiviral activity of Curcuma longa against Newcastle disease virus (in vitro and in vivo studies)

The antiviral activity of Curcuma longa against NDV on vero cell culture and in infected chicken was observed. The obtained results showed that low concentration of Curcuma longa 0.25% did not produce cytotoxicity on the...

Evaluation of the protective capacity of Toxocara canis embryonated egg antigen in rabbits

Toxocariasis is a disease of unspecific clinical manifestations in human beings and some animals forming a condition known as visceral larva migerans. Effective Toxocara canis (T. canis) control should destroy the dorman...

Prevalence of fungal pathogens in broiler chickens and their environment

Fungal diseases of poultry have become problematic as bacterial and viral diseases. This study was designed to investigate the prevalence of fungal agents in broiler chickens and their environment. The prevalence of fung...

Microbiological Quality of Retail Meats

A total of 220 random meat samples of different animal species were collected from 50 carcasses consisting 10 carcasses from each of beef, buffalo, camel, sheep and goat, as well20 frozen beef samples. Each carcass repre...

Download PDF file
  • EP ID EP658397
  • DOI -
  • Views 261
  • Downloads 0

How To Cite

M. Adam, M. A. Tohamy, S. E. El-Sadek, Abeer M. Radi (2016). Subcutaneous pharmacokinetic interaction of tulathromycin With flunixin meglumine in goats. Journal of Veterinary Medical Research, 23(2), 208-217. https://europub.co.uk/articles/-A-658397