Successful management of esthesioneuroblastoma with chemoradiotherapy: Report of 3 cases with review of literature
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2017, Vol 5, Issue 3
Abstract
Esthesioneuroblastoma (ENB) is a rare malignant tumour, which arises from the basal progenitor cells of the olfactory epithelium. Histopathological diagnosis is often difficult and is based on antigen detection by immunohistochemistry. The optimal treatment is still debated. Surgery followed by adjuvant radiotherapy is the recommended treatment for localised tumour, however, majority of the patients usually present in an advanced stage. We present a case series of three patients who were treated at our Institute with chemotherapy and radiotherapy between the years 2011 and 2016. Although no standard treatment protocol has been established, but combined modality therapy is the cornerstone of treatment for ENB. Chemotherapy can be added in advanced and metastatic disease. None of the patients received definitive surgical treatment. All three patients were treated by radiotherapy and chemotherapy, with endoscopic removal of the tumour done in one case. The patients were disease free during the follow-up period of 48 months, 14 months and 3 months.
Authors and Affiliations
Jaspreet Kaur
Keywords
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