Successful Salvage Treatment of Resistant Acute Antibody-Mediated Kidney Transplant Rejection with Eculizumab
Journal Title: Sultan Qaboos University Medical Journal - Year 2016, Vol 16, Issue 3
Abstract
Antibody-mediated rejection (ABMR) jeopardises short- and long-term transplant survival and remains a challenge in the feld of organ transplantation. We report the frst use of the anticomplement agent eculizumab in Oman in the treatment of a 61-year-old female patient with ABMR following a living unrelated kidney transplant. Te patient was admitted to the Sultan Qaboos University Hospital in Muscat, Oman, in 2013 on the eighth day post-transplantation with serum creatinine (Cr) levels of 400 µmol/L which continued to rise, necessitating haemodialysis. A biopsy indicated ABMR with acute cellular rejection. No improvement was observed following standard ABMR treatment and she continued to require dialysis. Five doses of eculizumab were administered over six weeks with a subsequent dramatic improvement in renal function. Te patient became dialysis-free with serum Cr levels of 119 µmol/L within four months. Tis case report indicates that eculizumab is a promising agent in the treatment of ABMR.
Authors and Affiliations
Saif A. Khan| Departments of Medicine, Sultan Qaboos University Hospital, Dawood Al-Riyami| Departments of Medicine, Sultan Qaboos University Hospital, Yasser W. Al-Mula Abed| Departments of Medicine, Sultan Qaboos University Hospital, Saja Mohammed| Departments of Medicine, Sultan Qaboos University Hospital, Marwa Al-Riyami| Departments of Pathology, Sultan Qaboos University Hospital, Nabil M. Al-Lawati| Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
Acute Idiopathic Pulmonary Haemorrhage in a 2 month old Infant Case report and review of the literature
Pulmonary haemorrhage is usually secondary to a systemic disease affecting the lung with or without other organ involvement. Idiopathic pulmonary haemorrhage is a diagnosis of exclusion; as described in the literature,...
Physicians’ Perceptions of Electronic Prescribing with Electronic Medical Records in Kuwaiti Primary Healthcare Centres
Objectives: This study aimed to evaluate physicians’ perceptions of electronic prescribing in Kuwaiti primary healthcare centres. Methods: This cross-sectional study was conducted between June and August 2017 among 368 p...
Paediatric Handbook
Gender Difference in Relationship of Apnoea/Hypopnoea Index with Body Mass Index and Age in the Omani Population
Objectives: Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a disorder characterised by repetitive upper airway collapse during sleep in association with daytime sleepiness. It has an estimated prevalence of 2%...
Causes of Stress and Coping Strategies Adopted by Undergraduate Health Professions Students in a University in the United Arab Emirates
Objectives: Tis study aimed to compare causes of stress and coping strategies adopted by a sample of undergraduate health-profession students at the Gulf Medical University, United Arab Emirates. Methods: An anonymous...