Superficial hyperthermia combined with hypofractionated radiotherapy of malignant melanoma metastases to skin and lymph nodes
Journal Title: Współczesna Onkologia - Year 2006, Vol 10, Issue 5
Abstract
Aim: The evaluation of combined radiohyperthermia in the treatment of skin and lymph nodes malignant melanoma metastases. Material and method: Material comprises 10 skin and 11 lymph nodes melanoma metastases (13 patients) treated with combined superficial hyperthermia and irradiation. The tumor diameter before the treatment varied from 0.5 to 7 cm (mean 2.9). All patients were treated using three 1 hour hyperthermia sessions and three 9 Gy radiation doses delivered within 8 days. The follow up period varied from 1 to 18 months (mean 4.6). Patients were examined on the day of treatment completion, 2 and 6 weeks later and next every three months. The skin reaction and tumor regression were evaluated. Impact of different biological factors for skin reaction and treatment result were checked. Results: The most frequent skin reaction was erythrema (51% of cases on the day of treatment end) and blisters (19% of cases 6 weeks after the treatment). Means of tumor diameter 0.5, 1.5, and 4.5 months after the treatment were 2.3, 2.3 and 2.4 cm, respectively. The biggest percentage of complete regressions was observed 1.5 and 4.5 months after the treatment, 33.5% and 43%, respectively. Significant dependencies between skin reaction 2 weeks after the treatment and red blood cells count in this time and before the treatment were found. Conclusion: The combined radiohyperthermia is safe and effective treatment modality of superficial melanoma metastases and could be an alternative for palliative surgery.
Authors and Affiliations
Leszek Miszczyk, Grzegorz Owczarek, Cezary Juda
Keywords
Related Articles
- EP ID EP128795
- DOI -
- Views 63
- Downloads 0
Screening in colorectal cancer (CRC)
Colorectal cancer (CRC) is one of major health problems in Poland. Every year about 11 000 new cases of CRC (EU about 220 000) are diagnosed; the number of deaths approaches 8 000 (EU 112 000). Five-year free disease sur...
Utylizacja radu 226 z ośrodka onkologicznego – ocena narażenia personelu
226Ra znalazł zastosowanie w terapii onkologicznej ze względu na długi okres połowiczego rozpadu i rodzaj emitowanego promieniowania. Po wielu latach stosowania zastąpiono go izotopami krótkożyciowymi, charakteryzujący...
Rola allotransplantacji krwiotwórczych komórek macierzystych w leczeniu guzów litych
Przeszczepianie allogenicznych krwiotwórczych komórek macierzystych (KKM) stało się uznaną metodą leczenia wielu nowotworów hematologicznych. Początkowe próby przeszczepiania allogenicznych KKM wykorzystywały technologię...
Pierwotny gruczolakorak wyrostka robaczkowego – opis przypadku
Pierwotny gruczolakorak wyrostka robaczkowego jest bardzo rzadkim nowotworem. W literaturze opisano mniej niż 250 przypadków. W artykule przedstawiono przypadek 48-letniej kobiety z objawami ostrego zapalenia wyrostka ro...
Surgical treatment of colorectal cancer