Surface and Interacellular Targets of Acute Myeloid Leukemia Therapy Detectable at Leukemic Stem Cell level
Journal Title: Haematology International Journal - Year 2018, Vol 2, Issue 1
Abstract
For over 50 years investigators have considered a malignant stem cell as the potential origin of and a key therapeutic target for acute myeloid leukaemia (AML) and other forms of cancer [1]. Leukaemic stem cells (LSCs) have been identified in acute myeloid leukaemia (AML). Similar to haemopoietic stem cells, these LSCs are able to self-renew, differentiate, and proliferate extensively. Recent studies suggest that LSCs are critical for the initiation and maintenance of leukaemia. Exciting new insights into the fundamental underpinnings of LSCs are now being made in an era in which drug development pipelines offer the potential to specifically target pathways of significance. This mini review will describe the possible targets expressed on the surface of AML, the intracellular targets and the novel molecular and flow cytometry methodologies being used to particularly ablate the LSC population.
Authors and Affiliations
Adhra Al-Mawali
Keywords
Related Articles
- EP ID EP291048
- DOI -
- Views 86
- Downloads 0
Cladribine an Alternative for Midostaurine in FLT3 Positive Acute Myeloid Leukemia
Midostaurinis registered for the indication newly diagnosed acute myeloid leukemia that is FLT3 mutation positive in combination with standard cytarabine and daunorubicine induction and cytarabine consolidation. The regi...
Surface and Interacellular Targets of Acute Myeloid Leukemia Therapy Detectable at Leukemic Stem Cell level
For over 50 years investigators have considered a malignant stem cell as the potential origin of and a key therapeutic target for acute myeloid leukaemia (AML) and other forms of cancer [1]. Leukaemic stem cells (LSCs) h...
Differential Correlation between Foetal Haemoglobin and Full Blood Count Based on Inherited Haemoglobin Type; A Cross-Sectional Study in Cape Coast, Ghana
1.1. Background: Foetal haemoglobin (Hb F) has been shown to modulate the severity of sickle cell anaemia (SCA). However, there is scarcity of data on the impact of Hb F levels in other inherited haemoglobin variants. Th...
Transfusion Support and Red Cell Alloimmunisation in Thalassemia Patients
Thalassemias are the most common mono genetic disease worldwide. It has high frequency extending from the Mediterranean basin through the Middle East (Iran), India and Southeast Asia. In India, the carrier rate of Beta T...
Ferritin Level in Pre and Postmenopausal Women Attending Usmanu Danfodiyo University Teaching Hospital Sokoto
Healthy individuals possess 3-4g of iron in his/her iron store, mostly in haemoglobin (oxygen-carrying pigment of blood) which is the most essential requirement of blood. Ferritin is a ubiquitous intracellular protein th...