SV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survival
Journal Title: Clinical Molecular Pathology - Year 2003, Vol 56, Issue 12
Abstract
Two cohorts of HCCs were studied. The first (cohort A) comprised 50 cases diagnosed between 1978 and 1989, and the second (cohort B) comprised 20 cases diagnosed between 1998 and 2001. Twenty cases of alcohol related cirrhosis diagnosed between 1978 and 1989 were also studied. Paraffin wax embedded, formalin fixed tissue blocks from all the above cases (tumour tissue for HCC cases and cirrhotic liver tissue for the alcohol related cirrhosis cases) were retrieved from the archival files of the department of pathology at the University of Edinburgh Medical School, UK. Haematoxylin and eosin stained sections of the carcinomas were reviewed by a gastrointestinal histopathologist (NW), taking into account the degree of differentiation (using the four point scale of Edmondson and Steiner),2 the main cell types (for example, hepatoid and/or clear), and the predominant growth pattern (trabecular, acinar, and/or solid). Date of birth, sex, and presence and type of any background liver disease were also compiled for each patient with HCC. All 70 patients with HCC had been managed at the Royal Infirmary of Edinburgh, UK. Patient details for cohort A were given to the Scottish Cancer Registry to enable a search for dates and registered causes of deaths. For any patients currently living at the time of our study, a survival time was calculated using 1 February 2003 as the census point. Our study was carried out in accordance with the guidelines of the Lothian local research ethics committee.
Authors and Affiliations
N A C S Wong, F Rae, M M Herriot, N J Mayer, D H Brewster, D J Harrison
Keywords
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- EP ID EP679618
- DOI 10.1136/jcp.56.12.904
- Views 42
- Downloads 0
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