Synchronous colorectal cancer
Journal Title: OncoReview - Year 2015, Vol 5, Issue 4
Abstract
Colorectal cancer is one of the most common neoplasms worldwide. It is still characterized by high mortality and causes ¼ of deaths due to neoplasms. Synchronous cancer is defined as presence of more than one cancer focus (not metastatic) in a patient at the same time. Prevalence of synchronous cancer amounts to 1.1–8.1% of all colorectal carcinomas. More often it affects elderly people and men. Risk factors include inflammatory bowel diseases, hereditary non-polyposis colorectal cancer and familial adenomatous polyposis. Molecular mechanisms underlying the synchronous lesions are: microsatellite instability (MSI), P53 and KRAS mutations as well as glutathione S transferase mutations (GST). In this article, we present a case of a 76-year-old woman with synchronous colorectal cancer in the form of tumors of the sigmoid colon and the ascending colon with metastasis in the liver.
Authors and Affiliations
Paweł Kozieł, Katarzyna Walkiewicz, Martyna Bednarczyk, Teresa Kokot, Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel
Keywords
Related Articles
- EP ID EP78727
- DOI 10.5604/20828691.1189735
- Views 213
- Downloads 0
The role of vena cava inferior filters in the prevention of venous thromboembolism prior to oncological surgeries
Venous thromboembolism represents one of the most important causes of complications and mortality in cancer patients. The therapy in this group of patients is mainly focused on adequate anticoagulant prophylaxis. In diff...
Aromataze inhibitors in the treatment of breast cancer
The main goal for hormonal therapy of breast cancer is to inhibit action of endogenous estrogens to breast cancer cells. Discovery of hormonal receptors and knowledge of their biological role employment to manner hormona...
Płyn w worku osierdziowym zagrażający tamponadą serca u chorych onkologicznie – standardy diagnostyki i leczenia
Obecność płynu w worku osierdziowym zagrażająca tamponadą serca jest stanem bezpośredniego zagrożenia życia. Najważniejsze w takim przypadku są: rozpoznanie, ustalenie wskazań do perikardiocentezy i drenaż jamy osierdzia...
Complications of palliative antiangiogenic therapy in patients with colorectal cancer
Introduction: Bevacizumab is an antiangiogenic drug used in the therapy of numerous solid tumours including colorectal adenocarcinoma. The efficacy and safety of bevacizumab has been demonstrated in many multicenter clin...
Severe aortic stenosis in a patient with breast cancer
We present a case of 68-year-old female with severe symptomatic aortic stenosis and locally advanced breast cancer disqualified from mastectomy due to heart failure and from aortic valve replacement due to malignant neop...