Synchronous colorectal cancer
Journal Title: OncoReview - Year 2015, Vol 5, Issue 4
Abstract
Colorectal cancer is one of the most common neoplasms worldwide. It is still characterized by high mortality and causes ¼ of deaths due to neoplasms. Synchronous cancer is defined as presence of more than one cancer focus (not metastatic) in a patient at the same time. Prevalence of synchronous cancer amounts to 1.1–8.1% of all colorectal carcinomas. More often it affects elderly people and men. Risk factors include inflammatory bowel diseases, hereditary non-polyposis colorectal cancer and familial adenomatous polyposis. Molecular mechanisms underlying the synchronous lesions are: microsatellite instability (MSI), P53 and KRAS mutations as well as glutathione S transferase mutations (GST). In this article, we present a case of a 76-year-old woman with synchronous colorectal cancer in the form of tumors of the sigmoid colon and the ascending colon with metastasis in the liver.
Authors and Affiliations
Paweł Kozieł, Katarzyna Walkiewicz, Martyna Bednarczyk, Teresa Kokot, Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel
Keywords
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- EP ID EP78727
- DOI 10.5604/20828691.1189735
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