Synergistic Activity of Thiadiazole And Thiazolidinone Derivatives Against Alloxan Induced Diabetes In Rats
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 3
Abstract
In our present investigation, different derivatives of 2-phenyl-3-(5-phenyl-1,3,4-thiadiazol-2-yl)-1,3-thiazolidin-4-one (3a-3e) were synthesized and evaluated for their antidiabetic activity by using the parameters like serum glucose, serum triglycerides, SGOT, SGPT, and body weight. The compounds were effective in normal values of described parameters. Among these 3a (benzaldehyde derivative) found to be more effective in decreasing the elevated serum glucose level (75.73±8.93 mg/dl) & body weight (214.54±2.75 gms) compared to standard (68.32±3.21 mg/dl) & (131.49±5.09 gms) respectively. The 3d (hydroxyl derivative) was found to be decrease serum triglycerides levels (155.56±13.91mg/dl) & SGOT levels (17.34±2.91) compared to standard (154.38±13.26 mg/dl) & (16.29±2.71) respectively. The 3e (dimethyl amine derivative) found to be decrease SGPT levels (16.13±3.11) when compared to standard (16.29±2.02). The investigation of activity reveled that 3a,3d,3e compounds showed good levels of antidiabetic activity. Keywords: Diabetic mellitus, SGOT, SGPT, serum triglycerides, serum glucose, alloxan, thiadiazole, thiazolidinone
Authors and Affiliations
M. Sai Harika, B. Naga Sudha, H. G Raghavendra
Keywords
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