Abstract

Objective: To investigate the synergistic effect of Commiphora mukul (gum resin) and Lagenaria siceraria (fruit) extracts in high fat diet induced obese rats. Methods: Rats were randomly divided into seven groups: (i) non-obese control (NOB), (ii) Obese control (OB), (iii) orlistat (50 mg/ kg; p.o. ), (iv) ethyl acetate extract of Commiphora mukul (gum resin) (200 mg/kg; p.o. ), (v) ethanolic extract of Lagenaria siceraria (fruit) (200 mg/kg; p.o. ) were examined individually, (vi) C. mukul and L.siceraria (200 mg/kg; p.o. ) and (vii) C. mukul and L.siceraria (400 mg/kg; p.o. )extracts were administered in combination to the high fat-diet-induced obese rats for 30 days to evaluate its synergistic activity. Results: For synergistic effect, after combination treatment caused most significant (P<0.001) reduction in body weight, fasting blood glucose, serum levels of cholesterol, triglyceride, LDL, VLDL and increase levels of HDL. Conclusions: The result demonstrated that combination C.mukul and L.siceraria has ameliorated the high fat diet induced obesity.

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