Syntezy i aktywność biologiczna pochodnych pirydopirydazyny
Journal Title: Wiadomości Chemiczne - Year 2014, Vol 68, Issue 1
Abstract
For many years all six isomers of pyridopyridazines have been an interesting class of heterocyclic compounds because of their biological and chemical properties. Endralazine is a hypotensive drug, which contain pyrido[4,3-c]pyridazine structure. Presented in this paper selected compounds exhibit antiviral [20] and antibacterial [21, 22] activity. Based on review of the chemical literature, derivatives of pyridopyridazine showed a multipharmacological effects such as analgesic [23–29] and diuretic [33–38] activity. Some chemical compounds, containing pyridopyridazine moiety showed anticancer activity in vitro with different mechanism of action [12, 15, 18, 19]. Novel pyrazolopyridopyridazine derivatives have been identified as more potent and selective phosphodiesterase 5 (PDE5) inhibitors than sildenafil [41]. Pyrido[2,3-d] pyridazine derivatives were synthesized as selective PDE4 inhibitors [44–46], with good selectivity profile and less undesiderable side effects. 2,3,8-Trisubstituted pyrido[ 2,3-d]pyridazines were novel classes of GABA-A receptor benzodiazepine binding site ligands [30, 31]. While pyrido[2,3-c]pyridazine derivatives were selective agonists for the benzodiazepine site of GABA-A receptor [32]. Some of new substituted pyrido[3,2-c]pyridazine derivatives possess molluscicidal activity [54] and can be used as biodegradable agrochemicals.
Authors and Affiliations
Wanda Paulina Nawrocka, Anna Nowicka
Keywords
Related Articles
- EP ID EP585220
- DOI -
- Views 128
- Downloads 0
Potencjalne zastosowanie enkefalin w diagnostyce i terapii różnych chorób
For the past few years enkephalins have been a center of appreciation and interest. Enkephalins were discovered in 1975 by Hughes, Kosterlitz and coworkers [1]. They can be described as short sequences of amino acids tha...
Areny jako proleki
Nowadays, improvement of physicochemical, biopharmaceutical and pharmacokinetic properties of pharmacologically active compounds is connected with development of prodrugs. Prodrugs are defined as pharmaceutical compounds...
Substancje aktywne preparatów do usuwania powłok lakierniczych
In most of paint removers organic solvent are used as active ingredients. The analysis of the literature on modern manufacture preparations allowed to identify the most commonly used solvent for this purpose i.e. methyle...
Modyfikacja chitozanu : krótki przegląd
Chitosan is the most important derivative of chitin, a polysaccharide found in the exoskeleton of shellfish like shrimp and crab. It is a product of deacetylation of chitin under alkaline conditions or enzymatic hydrolys...
Przegląd zastosowań spektroskopii w zakresie bliskiej podczerwieni w analizie wilgotności śladowej w produktach leczniczych weterynaryjnych immunologicznych
However, the infrared radiation has been discovered more than 200 years ago, near-infrared spectroscopy (NIRS), as a useful method, was recognized in the 1960s. Currently, under the influence of technological development...