SYNTHESIS AND ANTICANCER ACTIVITY OF NOVEL 1,3-THIAZOLE DERIVATIVES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 11
Abstract
2,5-disubstituted and 2,4-disubstituted thiazoles (2) and (3) were obtained from the reaction of 2,3-dihydroxybenzaldehyde thiosemicarbazone with p-chlorophenacyl bromide in different conditions. Acylation and alkylation of compound (2) and (3) with acetic anhydride and methyl iodide yielded the corresponding triacetyl derivatives (4 and 7) and N-methyl derivatives (5 and 8), respectively. Condensation of compound 3 with aromatic aldehyde in the presence of piperidine gave the corresponding aryl vinyl azo derivative (10a,b). Some thiazole derivatives were evaluated for their anticancer activity against MCF-7 and Hep-G2 cell lines. Among the tested compounds highest activity against liver carcinoma cells (Hep-G2) cell lines than the breast cancer (MCF-7) cell lines. The results showed that the investigated compounds (2,3,5,8) and (10a) had a significantly greater cytotoxic effect against human hepatocellualr carcinoma cells (Hep-G2) compared to that of other compounds (4) and (6).
Authors and Affiliations
Jehan A. Hasanen
Keywords
Related Articles
- EP ID EP619076
- DOI -
- Views 126
- Downloads 0
TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW
Skin is considered as the largest organ of the body and it has many different functions. The skin functions occur in thermoregulation, protection, metabolic functions and sensation. The skin is divided into two main regi...
CLINICAL EFFICACY OF PATHYADI KASHAYA AND THRIPHALA GHRITHA IN THE MANAGEMENT OF ANANTHAVATA WITH SPECIAL REFERENCE TO TENSION TYPE HEADACHE
Charaka Trimarmiya adhyaya highlights, Shiras is one major marma which seats for pranavata, alochaka pitta and tarpaka kapha. Imbalance of doshadhathu and mala related to the sirasa and manya pradesha will cause shiro ro...
PHARMACOKINETICS AND PK/PD MODELING OF AMOXICILLIN IN HUMAN MALE AND FEMALE VOLUNTEERS
The present study aimed to investigate the pharmacokinetic behavior in terms of Pharmacokinetic(PK)/Pharmacodynamic (PD) Modeling of amoxicillin in human male and female volunteers. For this purpose, ten healthy, adult m...
ORAL GLUCOSE TOLERANCE TESTS WITH A COMBINATION OF MOMORDICA CHARANTIA FRUITS AND TRIGONELLA FOENUM-GRAECUM SEEDS
Background: The fruits of Momordica charantia L. and seeds of Trigonella foenum-graecum L. are considered traditionally in Bangladesh to lower elevated blood glucose levels in glucose-impaired persons. The fruits and see...
PHARMACOKINETICS AND TISSUE RESIDUES OF MARBOCYL IN NORMAL AND AEROMONAS HYDROPHILIA INFECTED CATFISH (CLARIAS LAZERA)
The pharmacokinetics of marbocyl were studied following intravenous and intramuscular (single and repeated) administrations. Following a single intravenous injection of 10 mg/kg body weight of marbocyl in normal catfish...