Synthesis and anticancer evaluation of novel acenaphtho [1,2-e]-1,2,4- triazine derivatives
Journal Title: Eurasian Chemical Communications - Year 2019, Vol 1, Issue 0
Abstract
In this paper we present the convenient syntheses of seven new phenyl hydrazin derivatives 8 (a-h). For this purpose, acenaphtho [1,2-e]-1,2,4-triazine-9(8H)-thione (3) was prepared, starting from acenaphthylene-1, 2-dione (1) and thiosemicabazide in good yield. The reaction of (3) with benzyl chloride resulted to synthesis of 9-(benzylthio)-acenaphtho[1,2-e]-1,2,4-triazines (5) that reacted with hydrazine to synthesis of 9-(hydrazino)-acenaphtho [1, 2-e]-1, 2, 4-triazines (6). This compound reacted with different aromatic aldehyde derivatives (7 a-h) that resulted to synthesis of final product, 9-(phenyl imino hydrazine)-acenaphtho [1, 2-e]-1, 2, 4-triazine derivatives (8 a-h) in good yield. The cytotoxicity of the synthesized compounds were also studied against human cancer cell lines including breast (MCF-7), ovarian (SKOV3) and lung (A549) cell lines.
Authors and Affiliations
Somayeh Adibi Sedeh, Mohammad Kazem Mohammadi, Masood Fereidoonnezhad, Ali Javid
Keywords
Related Articles
- EP ID EP658123
- DOI 10.33945/SAMI/ECC.2019.5.6
- Views 172
- Downloads 0
Tramadol abuse and its related factors among higher education students in the city of Damghan, Semnan Province, Iran
Tramadol is an opioid analgesic with the potential for addiction to other opioids, and one of the abused drugs in different countries including Iran. The present study was conducted to determine the prevalence and factor...
Synthesis, characterization and spectroscopic properties of new azo dyes derived from aniline derivatives based on acetylacetone and azo-metal (II) complexes and singular value decomposition (SVD) investigation
Four new azo-dyes, 3-phenyl azopentane-2,4-dion (LA), 3-(4-nitro phenyl azo)-pentane-2,4-dion (LP), 3-(2-nitro phenyl azo)-pentane-2,4-dion (LO) and 4-(1-acetyle-2-oxo-propyl azo)-benzene sulfonate sodium (LS), were synt...
Synthesis of 2-arylbenzimidazole derivatives using nano montmorillonite clay as an efficient catalyst
Benzimidazoles are among the most important nitrogen-containing heterocyclic compounds that have many pharmaceutical applications, including antitumor, anticancer, anticorrosive, antibacterial, irritant and enzymatic int...
Evaluation of C60 nano-structure performance as nano-carriers of procarbazine anti-cancer drug using density functional theory methods
The study examined surface adsorption of fullerene C60 with anticancer drug procarbazine in gas and solvent (water) phases using the DFT method. In doing so, the structure of the procarbazine, fullerene and their derivat...
Study of structure and thermal properties of styrene-butylacrylate copolymer with OMMT nanocomposite emulsions
(St-co-BA) polymer through montmorillonite (MMT) nanocomposite emulsion is prepared by in situ intercalative emulsion polymerization of styrene (St), butyl acrylate (BA) in the presence of organic modified montmorillon...