Synthesis and anticonvulsant activity of certain chalcone based pyrazoline compounds
Journal Title: International Journal of Pharmacological Research - Year 2015, Vol 5, Issue 8
Abstract
Convulsions are involuntary, violent, spasmodic and prolonged contractions of skeletal muscles. That means a patient may have epilepsy without convulsions and vice versa. Epilepsy is a common neurological abnormality affecting about 1% of the world population. The primary objectives of these synthesized compounds are to suppress seizures and provide neuroprotection by minimizing the effects from seizure attacks. Here some of the chalcones and chalcone based various pyrazolines were evaluated for anticonvulsant activity. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR & Mass spectroscopy). A preliminary evaluation of the prepared compounds has indicated that some of them exhibit moderate to significant anticonvulsant activity compared to a diazepam standard1-3. All compounds were tested for their anticonvulsant activity using maximal electroshock induced convulsions (MES) in mice at a dose level of 4 mg/kg.b.w. The compounds Ph1, Ph2 , Py2 ,Py3 and Py4 have shown to good anticonvulsant activity when doses are administered as 25mg/ kg.b.w , reduced the phases of seizures severity and found to be active and also increased survival rate. Remaining compounds are less efficacious.
Authors and Affiliations
Sudhakara Rao Gerapati, Kalaichelvan V K, Ganguri Sudhakara Rao
Keywords
Related Articles
- EP ID EP434566
- DOI 10.7439/ijpr.v5i8.2409
- Views 83
- Downloads 0
Antimicrobial drugs usage in a tertiary care hospital A descriptive study
Background: Emergence of resistant organisms is alarmingly high all over the world. Irrational and inappropriate prescription of antimicrobials is the major contributing factor for developing drug resistance in addition...
Ovulatory Effect of Aloe Barbadensis Mill in Mature New Zealand Rabbit Does
Background: Ovulatory failure in females being the cause in 20-30% of infertility, the inability to conceive naturally or to carry out a pregnancy to full term or to deliver a healthy baby after trying for 1 year. Availa...
Phytochemical, trace metals assessment and antimicrobial efficacy of Barleria cristata
Traditional plants contains various secondary metabolites which have shown significant pharmacological activity. In the present paper, we analysed the phytochemical, trace metal and antimicrobial activity of ethanolic le...
Screening of cardioprotective activity of leaves of Andrographis paniculata against isoproterenol induced myocardial infarction in rats
Objective: The objective of the present study was to investigate the cardioprotective effects of methanolic extract of leaves of Andrographis paniculata against Isoproterenol-induced myocardial infarction (MI) in rats....
Efficacy and safety of oral vitamin D (cholecalciferol) supplement therapy in Stage I primary hypertension; a prospective, randomized, double-blind, placebo controlled, clinical trial in a tertiary care hospital in central India
Introduction: Hypertension is one of the most common cardiovascular disorders. Almost all targets in its therapy are exploited and there is a growing need to search for newer targets. Vitamin D is gaining increasing atte...