Synthesis and Antimicrobial Activity of some Novel Isoindoline-1,3-Dione Derivatives
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 8, Issue 2
Abstract
New phthalimido derivatives incorporated with chalcone, pyrazole, pyrazoline, and pyrimidine moieties were synthesized and evaluated for their antimicrobial activities against bacterial and fungal strains. 2-{4-[1-Acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl} isoindoline-1,3-dione (7) showed broad spectrum antibacterial activity against both G+ and G- bacteria. While, (E)-2-{4-[3-(4-chlorophenyl)acryloyl]phenyl}isoindoline-1,3-dione (4b) showed promising antifungal activity.
Authors and Affiliations
Phoebe F. Lamie
Keywords
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- EP ID EP652684
- DOI 10.24297/jac.v8i2.5570
- Views 137
- Downloads 0
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