Synthesis and Antimicrobial Evaluation of some novel 4-[4-(3-chloro-2oxo-4- substituted-phenylazetidin-1-yl)phenylamino]-1,2-dihydro-2,3-dimethyl-1- phenylpyrazole-5-one
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
A series of eight novel 2-Azetidinones (4a-h) have been synthesized by cyclocondensation of various Schiff bases of 4-[(4-aminophenyl)amino]- 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one with chloroacetyl chloride in presences of triethylamine. Various Schiff bases were synthesized by condensation of 4-[(4-aminophenyl)amino]-1,5-dimethyl-2- phenyl-1,2-dihydro-3H-pyrazol-3-one with various arylaldehydes (3a-h). The synthesized compounds (4a-h) were screened for their antibacterial activity gainst six microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Grampositive), Salmonella typhi (Gram negative) Escherichia coli (Gram negative) and fungal strain Aspergilius niger & Candida Albicans. They were found to exhibit good to moderate antibacterial activity. Among the eight derivative comp no-4e show the good activity.The structures were confirmed by IR, 1H- NMR and Mass spectral data.
Authors and Affiliations
Ajay Kr Yadav, Indu Shukla, Chhaya R Sahu, S. R. Sahu
Keywords
Related Articles
- EP ID EP222208
- DOI -
- Views 87
- Downloads 0
DEVELOPMENT AND VALIDATION OF SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF APIXABAN IN API AND ITS BULK DOSAGE FORM
Abstract Simple, rapid, sensitive, precise and specific UV spectrophotometric method for the determination of Apixaban in bulk drug and pharmaceutical dosage form were developed and validated. In this method solution of...
INCREASED RISK OF ENDOMETRIAL CARCINOMA AND ACCURACY IN THE DIAGNOSIS OF PATIENTS: A GYNECOLOGIC STUDY
In sharp difference to numerous other tumor sorts, the occurrence and mortality of endometrial disease keep on growing. This awful pattern is, in no little section, an aftereffect of the overall corpulence pandemic. The...
A REVIEW ON SOLID DISPERSIONS DRUG DELIVERY SYSTEMS
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation t...
FORMULATION AND EVALUATION OF GEL BASED ON BORASSUR FALBELLIFER AS A GELLING AGENT
Natural gums and mucilages have been extensively explored as pharmaceutical excipients. These gums and mucilages are biocompatible, cheap and easily available. The present study was undertaken with an objective to find o...
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-(4-CHLOROPHENYL)-2-(3-SULPHOXYPHENYL-4-(4-SUBSTITUTED BENZYLIDENE)-5-IMIDAZOLONES
Abstract Imidazolones are believed to be associated with several pharmacological activities. Their significance lies in the fact that they show diverse biological activities. Which include anticancer, anticonvulsant, ant...