Evaluation and Comparison of Highly Soluble Sodium Stearyl Fumarate with Other Lubricants In Vitro
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2013, Vol 3, Issue 12
Abstract
Lubricants are the essential components of all solid dosage forms. Sodium stearyl fumarate is sparingly soluble in water. An attempt has been made to improve solubility of sodium stearyl fumarate to become it highly soluble. Sodium stearyl fumarate was compared with other conventional lubricants to check the impact of lubricants on flow properties, hardness, and disintegration and dissolution characteristics. Different concentrations of lubricants were used to prepare uncoated tablets and evaluated for its activity. All the tablets prepared with sodium stearyl fumarate were found to be better in terms of variations in hardness, disintegration and dissolution property. Hence, sodium stearyl fumarate was a super lubricant in tablet dosage form.
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