Synthesis and Biological Evaluation of Fluorescein-Tagged 1-Methyl-o-carborane for Boron Neutron Capture Therapy
Journal Title: Annals of Advances in Chemistry - Year 2018, Vol 2, Issue 1
Abstract
Fluorescein was conjugated with 1-methyl-o-carborane and the resulting bioconjugate was biologically evaluated through microscopic and flow cytometric studies in pancreatic cancer and squamous cell carcinoma cell lines. The uniform distribution of this bioconjugate, as well as its moderate cytotoxicity and higher boron content relative to present boronated delivery agents sodium borocaptate (BSH) and boronophenylalanine (BPA), provide justification for its further evaluation as a potential delivery agent for BNCT.
Authors and Affiliations
SF Elsawa, LA Kuzmanic, LE Zuidema, Misurelli Jason A, Uno Kazuko, Takagaki Masao, Hosmane Narayan S
Keywords
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- EP ID EP538309
- DOI 10.29328/journal.aac.1001016
- Views 56
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