Synthesis and characterization of coumarin-4-thiazolidinone scaffolds as new class of anti-tuberculosis and antibacterial agents
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 7
Abstract
Our recent research target was to design biological active coumarin-4-thiazolidinone derivatives by using coumarin Schiff base which is pharmacologically and medicinally important scaffold. Synthesized novel coumarin-4-thiazolidinone derivatives were evaluated for their in vitro anti-tuberculosis activity against Mycobacterium tuberculosis strain H37Rv and showed moderate activity with MIC 25-100μg/mL. The antibacterial activity were also evaluated for synthesized compounds, among them compounds 5a and 5o showed the highest activity with MIC 1.6μg/mL and 0.8μg/mL respectively and these two are found to be more sensitive compounds against Gram positive bacterial strains S.aureus and B.subtilis.
Authors and Affiliations
Jyoti M. Madar, Lokesh A. Shastri, Samundeeswari L. Shastri, Megharaj Holiyachi, Nirmala S. Naik, Farzanabi Shaikh, Vinay A. Sungar, Shrinivas D. Joshi
Keywords
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