Synthesis and Characterization of Microporous Cryogel Matrices with Anti-inflammatory Effect
Journal Title: International Journal of engineering Research and Applications - Year 2018, Vol 8, Issue 7
Abstract
The aims of this paper are the synthesis, the physicochemical characterization and in vitro analysis of microporous cryogels matrices. Polyvinyl-alcohol (PVA) is a non-toxic linear polymer, highly soluble in water, resistant to organic solvents and frequently used in medical applications. ketoprofen is a non-steroidal antiinflammatory drug used in various topical and oral pharmaceutical forms. Cryogelation is a technology that makes interconnected pore structure in moderately frozen condition after four freeze/thaw cycles. The morphology of the cryogels, the interaction between the PVA macromolecular chains and ketoprofen has been studied by Scanning Electronic Microscopy. The gels swelling in physiologic medium have been monitored in order to establish the hydrophilic properties. The mechanical properties of the cryogels have been investigated by dynamic mechanical measurements and the concentration of ketoprofen released by spectrophotometry. The new microporous cryogel matrices shows good physical, morphological and drug release properties.
Authors and Affiliations
Monica Iliuta Stamate, Ciprian Stamate
Keywords
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