SYNTHESIS AND CHARECTERIZATION OF PHARMACEUTICAL POLYMERS IN ALKALINE MEDIUM FOR CONTROLLED DRUG DELIVERY SYSTEM
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 3
Abstract
The aim was to synthesized pH dependent polymers in different monomeric ratio, which were intended to be used for controlled drug delivery system. In this study we took monomers which were previously synthesized. i.e. Methylmethacrylate (MMA) and Acrylic Acid(AA) in different ratio (in moles) as follow-MMA:AA(0.7:0.3), MMA:AA (0.6:0.4),MMA:AA (0.5:0.5),MMA:AA(0.4:0.6) and MMA:AA(0.3:0.7) with solvent Tetrahyrdrofuran(THF) and Azobis-isobutyronitrile (AIBN) Initiator, which under goes polymerization. Polymers were prepared by solution polymerization technique and free radical mechanism. Swelling behavior of different polymeric films (polymers) which have obtained from polymerization in different monomeric ratios, studied in different pH buffer solutions. The different pH buffer solutions were Hydrochloric acid buffer pH 1.2, Hydrochloric acid buffer pH 2.0, Phosphate buffer pH 6.0, Phosphate buffer pH 7.4, Phosphate buffer pH 8.0.These different pH buffer solutions were prepared according to Indian Pharmacopoeia 2007. The changes in polymeric films in phosphate buffer (pH 8.0, pH 7.4) after 15,30, 45,60,75,90,120 minutes were noted. In buffer ( pH 6.0, pH2.0, and pH 1.2) the changes were noted after 1 hour,2hours,2 days,3 days,4 days,5 days,6 days,7 days. Swelling ratio calculated by formula. For microencapsulation paracetamol drug was taken as a model drug. Emulsification solvent evaporation method have used for micro encapsulation of model drug. The standard calibration curve of paracetamol obtained a straight line. The relation between drug concentration & absorbance measured at 249 nm found linear. The standard calibration curve obeys Bear’s Lambert law within the concentration range of 0.0005mg/ml to 0.00003mg/ml. The drug was estimated by UV spectrophotometer at 249 nm using a calibration curve based on standard solutions. The percentage of paracetamol encapsulated with respect to total amount of paracetamol encapsulation taken loading efficacy. In vitro dissolution release of paracetamol from micro spheres was evaluated using paddle dissolution apparatus (Lab India Disso 2000 dissolution tester). Dissolution media was 900 ml phosphate buffer (pH 7.4) & to this media the microspheres containing 200 mg of paracetamol were added. The system was stirred at 500 pm & temp at 37oC± 0.5 oC . Samples were drawn at specified time intervals (10 min, 20 min, 30 min, 40 min, 50 min & 60 min) filtered & assayed spectrophotometrically at 249nm. For swelling study, all the copolymers in different monomeric ratio did not show good swelling or dissolution characteristic in acidic pH (pH 1.2-pH6.0) methylmethacrylate: acrylic acid with monomer ratio 3:7 completely dissolved within 2 hours. Keywords: Polymers, Methylmethacrylate, Acrylic acid, Ultraviolet Spectrophotometer, Dissolution apparatus
Authors and Affiliations
SANDEEP GAUR*| Department Of Pharmaceutical Sciences, Shri Venkateshwara University, Gajraula, Distt-J.P.Nagar (U.P.) India., RAJBALA SHARMA| Department Of Pharmaceutical Sciences, Shri Venkateshwara University, Gajraula, Distt-J.P.Nagar (U.P.) India.
Keywords
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