Synthesis and Evaluation of Antibacterial Activity of Novel Azaindole Derivatives
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Azaindoles are an important class of nitrogen containing heterocyclics and were identified as the most active and potent classes of compounds with wide range of biological and pharmacological activities. They were extensively used as pharmaceuticals. Although the number of drugs are available in the market even though the search for new molecules is ever demanding. In present work various Azaindoles were synthesized and characterized using physical and spectral data. Finally, the Azaindole derivatives were screened for their In vitro antibacterial activity. Some of the molecules exhibited very good potency when compared with respective standards. The approach is very challenging and was found difficult to get a molecule with potency. Even though, the present molecules were provided novel leads against gram +ve and gram –ve bacteria.
Authors and Affiliations
Rajashekar Vadlakond, Raghunandan Nerella2, S Vijaya Srinivas3 ,, Upender Rao Eslawath4
Keywords
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