Phytochemical, Antibacterial, Antiinflammatory And Analgesic Studies On Swertia Tetragona Edgew
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Objective: To evaluate whole plant extracts of Swertia tetragona Edgew for antibacterial, antiinflammatory and analgesic activity. Methods: Hydroacholic extract of powdered S. tetragona Edgew whole plant was prepared by Soxhlet apparatus using Ethanol: Water in a ratio of 80:20. The aqueous extract was prepared using cold maceration technique. The phytochemically analysis, HPTLC fingerprinting and pharmacological evaluation were carried out using standard procedures.Results: Phytochemical analysis revealed the presence of alkaloids, flavonoids, proteins, saponins and sterols. The phytochemical analysis was supported by HPTLC fingerprinting, which showed 12 peaks representing the phytochemical constituents present. The pharmacological evaluation revealed that both extracts possess good antiinflammatory activity (depicted by % inhibition of inflammation by 70.00 %, 72.10% and 74.07 % for hydro-alcoholic extract and 56.00 %, 59.00 % and 66.66 % for aqueous extract. The standard acelofenac decreased inflammation by 62.00 %, 64.05 % and 66.66 % under identical experimental conditions 1,2 and 3 hours post treatment) and analgesic activity (depicted by delay in reaction time in seconds by 8.5, 9 and 8.7 by hydro-alcoholic extract; 8.1, 7.8 and 7.5 by aqueous extract). Under identical experimental conditions standard acelofenac delayed reaction time by 9.5, 9.5 and 8.5 seconds when tested by tail flick, tail clip and hot plate methods respectively. The antibacterial evaluation revealed that hydro-alcoholic extract exhibited antibacterial potential, which was more for gram positive bacteria than gram negative.Conclusion: Both extracts of S. tetragona Edgew have anti-inflammatory and analgesic potential. However, antibacterial potential was only shown by hydroalcoholic extract.
Authors and Affiliations
Bader GN, Naqash A, Ahad P, Ali S
Keywords
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