Synthesis and evaluation of antiviral activities of novel sonochemical silver nanorods against HIV and HSV viruses
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2016, Vol 6, Issue 11
Abstract
Objective: To evaluate the effect of novel sonochemical silver nanorods on HIV and herpes simplex virus type 1 (HSV-1) viruses in human cervical cancer HeLa cells. Methods: The formation of silver nanorods conjugated with sodium 2-mercaptoethane sulfonate (Ag-MES) was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric analysis. The antiviral activity of this Ag-MES was examined against HIV and HSV-1 virus replication. Results: The characterizations of Ag-MES and physiochemical structure were determined by scanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric analysis. Approximately entire viral replication was inhibited by Ag-MES at 10 µmol/mL concentration. About 90% of HSV virions failed to replicate in the present of this concentration of nanorods. However, HIV showed more sensitivity to Ag-MES than HSV-1. Conclusions: According to the obtained data, the synthesized sonochemical silver nanorod in this study is a promising candidate for further drug discovery investigation.
Antidiabetic and antioxidant potentials of spent turmeric oleoresin, a by-product from curcumin production industry
Objective: To investigate the antidiabetic and antioxidant activity of spent turmeric oleoresin (STO). Methods: Antidiabetic activity of STO evaluated by α - amylase and α - glucosidase enzyme inhibition assays. The anti...
Elementary of animal model for percutaneous and ocular penetration
Models of animal are the most appropriate method for assessments of human in-vivo percutaneous and ocular penetrations. Monkey and rodents are used for the same. There are several nuts and bolts of each one, so it is nec...
Bacteriological and parasitological assessment of currencies obtained in selected markets of Metro Manila
Objective: To assess the bacterial and parasitic contamination of coins and paper bills obtained in selected public markets of Metro Manila. Methods: Money collected from the markets was assessed through culture, microsc...
Internal hirudiniasis in a hen (Gallus gallusdomesticus)-The first report in literature
The leech is a blood sucking worm belonging to the class Hirudinea of the phylum Annelida. Leeches are commonly found in the waterland of temperate and tropical countries. Hirudiniasis, a rare condition with unusual symp...
Proximate composition, phytochemical screening, GC-MS studies of biologically active cannabinoids and antimicrobial activities of Cannabis indica
Objective: To investigate the proximate composition, minerals analysis, phytochemical screening, gas chromatography-mass spectrometry (GC-MS) studies of active cannabinoids and antimicrobial activities of Cannabis indica...