SYNTHESIS AND EVALUATION OF SOME NEW 6-FLURO-QUINOLIN-4 (1H)-ONE DERIVATVES FOR THEIR ANTI-MICROBIAL ACTIVITIES
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
The present work is a bonafide and novel for the synthesis of 6-fluro-quinolin-4(1H)-one derivatives. Around 30 new derivatives were synthesized, with the standard chemicals and well established procedures. The synthesized compounds were tested for their preliminary tests, physical constants, TLC, solubility, etc. IR, 1H-NMR Spectra and CHN analysis confirmed the structures of the final compounds. The proposed compounds were screened for their antimicrobial, antifungal, antitubercular and anti-inflammatory activities with the standard drugs in the well-equipped microbiology and pharmacology lab by using standard methods.
Authors and Affiliations
Shashikant . R . Pattan , Nachiket S Dighe , C K Hariprasad ,Jayshari S Pattan , Arati V Daithankar , Vinayak M Gaware , Mangesh B Hole
Keywords
Related Articles
- EP ID EP129128
- DOI -
- Views 81
- Downloads 0
Studies in Formulation Development of Low Dose Content Drug Using Fluid Bed Granulation Technique
To achieve acceptable content uniformity, a granulation process is generally utilized. Fluid bed granulation, wet granulation, dry granulation was used for granulation purpose for formulation of sustained release tablets...
Development and Characterization of Curcumin Loaded Transfersome for Transdermal Delivery
The aim of the present cram was to investigate the potential of a tranfersomes formulation for transdermal delivery of Curcumin. Curcumin is widely used in potent anti-inflammatory herbal drug. Its activity is...
Pharmacokinetics of Ecofriendly Meloxicamin Healthy Dogs
Meloxicam has been reported as an eco-friendly alternate of diclofenac sodium which was banned for veterinary use during 2005-06, due to its relay toxicity associated with the catastrophic decline in vulture populations...
Formulation and Evaluation of Piroxicam dispersible tablets using Natural disintegrants
The objective of necessary work to develop Piroxicam dispersible tablets using natural disintegrants which would release the drug rapidly with predetermined rate. Six batches of Piroxicam dispersible tablets were&nb...
Effect of Costus speciosus and Wedelia chinensis on Brain<br /> Neurotransmitters and Enzyme Monoamine Oxidase Following Cold Immobilization Stress
The effect of alcoholic extracts of Costus speciosus rhizomes and Wedelia chinensis leaves were evaluatedon stress induced changes in brain neurotransmitters and enzyme monoamine oxidase levels in albino rats.The e...