SYNTHESIS AND FLUORESCENCE STUDY OF A SERIES OF 4-HYDROXYCOUMARIN O-ACYLATION DERIVATIVES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 1
Abstract
Some coumarin derivatives were synthesized starting from 4-hydroxycoumarin and benzoyl chlorides. The structures of the obtained compounds were confirmed by mass and NMR spectra. Additionally, their crystal structures were determined by X-ray diffractometry, excepting the compound C1. Absorption and fluorescence spectra of these derivatives have been investigated in acetonitrile medium. The effects of various electron donating substituents R on fluorescence emission were examined. As a result, compound C5 with an electron-donating substituent dimethyl amino (R = Me2N) exhibited the strongest fluorescence.
Authors and Affiliations
Abdoulaye Djandé
Keywords
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