SYNTHESIS AND GREEN BROMINATION OF SOME CHALCONES AND THEIR ANTIMICROBIAL SCREENING
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 4
Abstract
Chalcones are the versatile molecules having the structural flexibility which permits structural transformations into flavonoids, flavanones, pyrazoles, oxazoles, pyrimidines etc. Changes in their structure have offered the development of new medicinal agents having improved pharmacological potency. Their derivatives have attracts increasing attention due to numerous pharmacological potential. In the present communication we report the synthesis of chalcones from various acetophenone derivatives with different aromatic aldehydes and green chemistry approach to their bromination with the help of Tetrabutylammonium Tribromide (TBATB). All the synthesized chalcone dibromides were screened for their antimicrobial activity against Aspergillus flavus, Rhizopus sp., Fusarium solani and Aspergillus niger.
Authors and Affiliations
Mayur Adokar
Keywords
Related Articles
- EP ID EP151423
- DOI 10.7897/2230-8407.04438
- Views 77
- Downloads 0
DEVELOPMENT AND CHARACTERIZATION OF FLOATING MICROSPHERES OF CLARITHROMYCIN AS GASTRORETENTIVE DOSAGE FORM
In the present study, an attempt has been made to prepare floating microspheres of clarithromycin designed as gastroretentive dosage form for the treatment of Heliobacter pylori. The floating microspheres were prepared...
CLINICAL IMPORTANCE OF SUSHRUTOKTA DWADASHAVIDHA PARIKSHA
A patient constitutes karyadesha, that’s why patients should be examined thoroughly to obtain the knowledge of life span, strengths and intensity of morbidity because treatment may be initiated after knowing the intensit...
ISOLATION AND FREEZE DRYING OF CERTAIN PROBIOTIC STRAINS
The aim of the present study was to evaluate few probiotics strains available commercially in Lahore city and isolation and identification of strains from these commercial probiotics. The identified and isolated probioti...
EFFECT OF YASADA BHASMA ON ORAL SODIUM PHOSPHATE INDUCED NEPHROCALCINOSIS IN RATS
Nephrocalcinosis is a condition characterized by calcium salt deposits in the kidneys which may affect it's ability to function. Nephrocalcinosis is caused by a number of conditions including: the excess excretion of cal...
IN VITRO ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES EVALUATION OF METHANOLIC EXTRACT OF CAESALPINIA PULCHERRIMA FLOWERS
The current study was conducted to prove ethno medicinal value of the plant, investigating anti-microbial, antioxidant, and total phenolic content of crude methanolic extract of flowers of Caesalpinia pulcherrima. The me...