DEVELOPMENT AND CHARACTERIZATION OF FLOATING MICROSPHERES OF CLARITHROMYCIN AS GASTRORETENTIVE DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 1
Abstract
In the present study, an attempt has been made to prepare floating microspheres of clarithromycin designed as gastroretentive dosage form for the treatment of Heliobacter pylori. The floating microspheres were prepared using different polymers like HPMC- ethyl cellulose, HPMC, eudragit S-100, eudragit L-100, by solvent evaporation/diffusion methods which offer advantage of short processing time, lack of exposure of the ingredients to high temperature and gives high encapsulation efficiency. Formulations were characterized for their particle size, practical yield, entrapment efficiency, in vitro buoyancy, drug polymer compatibility (IR), scanning electron microscopy (SEM) and in vitro drug release. Scanning electron microscopy shows that spherical microspheres with porous surface were formed .The optical microscopic studies revealed that the practical yield was more than 61.35% with a particle size range of 105.61-325.15 µm. The percent entrapment efficiency is about 62.68% and more in larger particle as compared to smaller particle. The percent buoyancy was more than 71.40% up to 12 hours. The particle size, percent yield, percent drug entrapment and percent was increased significantly with increase in polymer concentration. The in vitro release was significantly decreased with in polymer concentration. The release obeys first order kinetics model and the drug release rate was diffusion controlled with Fickian or non-Fickian transport depending upon the polymers. The prepared floating microspheres were stable. Hence it can be inferred that the floating microsphere of clarithromycin as a gastroretentive dosage form may prolong drug release there by improving bioavailability and enhance opportunity of drug absorption in stomach to prevent degradation of drug under alkaline pH.
Authors and Affiliations
Aejaz A, Sadath A
Keywords
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