SYNTHESIS AND INVESTIGATION OF ANTHELMINTIC, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF 3,3-DIPHENYL PROPANAMIDE DERIVATIVES
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 1
Abstract
Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investigated for anthelmintic, antibacterial, and antifungal activity.Methods: All the compounds were characterized by infrared (IR) and1H- nuclear magnetic resonance spectrometry data. The synthesized derivatives were investigated for their anthelmintic activity employing housefly worms method and earthworm species model. The antibacterial and antifungal activity was performed employing cup plate method.Results: The synthesized compounds (VII and VIII) exhibited maximum anthelmintic activity as compared with standard drug albendazole at doses of 50 and 100 mg/mL, due to minimal paralyzing and death time in both housefly and earthworm models. The compounds (IV, VII, and VIII) at 50 μg/mL exhibited maximum activity against Gram-negative bacterial strains, namely, Escherichia coli, Pseudomonas aeruginosa as compared with ciprofloxacin and same compounds exhibited maximum antifungal activity against Candida albicans and Aspergillus niger in comparison with standard drug griseofulvin at 50 μg/mL.Conclusion: The synthesized compounds bearing amino acid moiety in their structure (VII-VIII) exhibited impressive anthelmintic activity in comparison with albendazole. This suggests that amino acid/peptide derivative of diphenyl propanamides can act as great anthelmintic agents. Further, the research can be performed to design potent antimicrobial diphenyl propanamide derivatives.Â
Authors and Affiliations
Sachin Chaudhary, Harish Chandra Verma, Mandeep Kumar Gupta, Ramesh Kumar Gupta, Amit Kumar, Abdel Nasser El-shorbagi
Keywords
Related Articles
- EP ID EP607152
- DOI 10.22159/ajpcr.2019.v12i1.30094
- Views 97
- Downloads 0
KNOWLEDGE AND PERCEPTIONS OF SELF-MEDICATION PRACTICES IN AN URBAN COMMUNITY
Objective: This study was conducted with the aim to assess the knowledge and attitude of self-medication practices among the residents of an urban community. Methods: A cross-sectional, observational study was conducted...
EXPRESSION OF CANCER STEM CELL MARKER OCTAMER-BINDING TRANSCRIPTION FACTOR 4 IN HIGH-GRADE TRANSITIONAL CELL CARCINOMA
Objectives: The objectives of this study were to provide an outlook of urothelial carcinoma through the immunohistochemical expression patterns of octamer-binding transcription factor 4 (OCT4) in high-grade transitional...
BIOMEDICINAL AND GASTROPROTECTIVE ASPECTS OF ORGANOBISMUTH COMPOUNDS: RECENT APPROACHES AND FUTURE PERSPECTIVES
Objective: Peptic ulcer is a disease caused due to an imbalance of aggressive and defensive factors in the body. Helicobacter pylori infections and colonization are also associated strongly to the peptic ulcer disease. B...
INVITRO ANTIOXIDANT ACTIVITIES OF VARIOUS LEAVES EXTRACTS FROM FIVE VARIETIES OF RAMBUTAN (Nephelium lappaceum) AND ITS CORRELATION WITH TOTAL FLAVONOID, PHENOLIC, CAROTENOID CONTENT
 Objectives: The objectives of this research were to study antioxidant activity from different polarities extracts of rambutan (Nephelium lappaceum) leavesusing two methods of antioxidant testing which were 2-2-diphenyl...
ASSESSMENT OF SMOKING BEHAVIOR AMONG MALAY MALE SMOKERS IN KELANTAN, MALAYSIA
Objective: The aim of this study was to assess smoking behavior among Malay male smokers in Kelantan, Malaysia.Methods: Volunteers (n=496) were recruited in the study by randomly selected manner. The participants were ca...